Patricia Coe

Learn More
This report describes the relationship between the pharmacokinetics, antitumour activity and toxicity of chlorambucil (CHL), phenylacetic acid mustard (PAAM) and β,β-difluorochlorambucil (β-F2CHL) in mice. Pharmacokinetics were studied by HPLC, antitumour activity by a regrowth delay assay using the KHT murine sarcoma and toxicity by acute LD50. For both(More)
OBJECTIVES The objective of this study was to determine the change in blood pressure (BP) in normotensive and prehypertensive adults resulting from a therapeutic massage, and the factors associated with such changes, including demographic and massage characteristics. DESIGN SETTINGS/LOCATION National University of Health Sciences Massage Therapy(More)
A series of 5-substituted 2'-deoxy-4'-thiopyrimidine nucleosides was synthesized and evaluated as potential antiviral agents. A number of analogues such as 2'-deoxy-5-propyl-4'-thiouridine (3ii), 2'-deoxy-5-isopropyl-4'-thiouridine (3iii), 5-cyclopropyl-2'-deoxy-4'-thiouridine (3iv), 2'-deoxy-4'-thio-5-vinyluridine (3viii), and(More)
A practical 7-step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides. These novel nucleoside analogues have potentially useful biological activity and are resistant to phosphorolysis.
This paper describes the silicon microstrip modules in the barrel section of the SemiConductor Tracker (SCT) of the ATLAS experiment at the CERN Large Hadron Collider (LHC). The module requirements, components and assembly techniques are given, as well as first results of the module performance on the fully-assembled barrels that make up the detector being(More)
The antiviral activity of several nucleoside analogues is often limited by their rapid degradation by pyrimidine nucleoside phosphorylases. In an attempt to avoid this degradation, several modified nucleosides have been synthesized. A series of 4'-thio-2'-deoxyuridines exhibits an anti-[herpes simplex virus (HSV)] activity significantly higher (20-600(More)
OBJECTIVE The purpose of this study was to determine the amount and type of negative side-effects and positive (unexpected) effects experienced after a massage session. STUDY DESIGN Cross-sectional. SETTING Massage clinic at a health sciences university. SUBJECTS Of the 100 new and returning massage therapy clients who agreed to participate, 91(More)
In seeking to block and thereby determine the role of the rapid in vivo hydroxylation of the cyclohexyl moiety of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in relation to antitumor activity and tissue distribution, the 3-(1H-decafluorocyclohexyl) analogue (FCCNU) was synthesized. FCCNU showed marked toxicity and little activity against the(More)
A novel fluoropyrazole ribonucleoside has been shown to have significant anti-influenza activity in vitro. The compound is compared and contrasted with the structurally-related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds.
P. Bambade,* M. Alabau Pons, J. Amann, D. Angal-Kalinin, R. Apsimon, S. Araki, A. Aryshev, S. Bai, P. Bellomo, D. Bett, G. Blair, B. Bolzon, S. Boogert, G. Boorman, P. N. Burrows, G. Christian, P. Coe, B. Constance, J.-P. Delahaye, L. Deacon, E. Elsen, A. Faus-Golfe, M. Fukuda, J. Gao, N. Geffroy, E. Gianfelice-Wendt, H. Guler, H. Hayano, A.-Y. Heo, Y.(More)