Patricia Brown

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A three base-pair deletion in the widely expressed TOR1A gene causes the childhood onset, neurological disease of DYT1 dystonia. Mouse Tor1a gene knockout also specifically affects the developing nervous system. However, in both cases, the basis of neuronal tissue specificity is unknown. TorsinA is one of four predicted mammalian torsin ATPases associated(More)
Foraging and echolocation behavior and its ontogeny in the lesser bulldog bat, Noctilio albiventris, were studied in Panama under field and captive conditions. The vocalizations utilized for echolocation and communication were monitored. Adult N. albiventris captured insect prey from the water surface employing various combinations of CF/FM (constant(More)
1. Adult pallid bats possess auditory capabilities similar to those of other echolocating Vespertilionids, albeit with unusually great sensitivity to frequencies below 15 kHz. 2. Newborn bats show no behavioral or neurophysiological responses to auditory stimuli. 3. Evoked potentials were detected first in a six day old bat in response to loud, low(More)
OBJECTIVE To identify potential genetic modifiers contributing to the phenotypic variability that is detected in patients with repeat expansions in chromosome 9 open reading frame 72 (C9ORF72), we investigated the frequency of these expansions in a cohort of 334 subjects previously found to carry mutations in genes known to be associated with a spectrum of(More)
BACKGROUND Although whole population screening for type 2 diabetes is not currently considered to be justified, targeted screening within higher risk groups may be more cost-effective, and more pragmatic. OBJECTIVES Our aim was to investigate the feasibility and performance of a pragmatic system for identifying patients with type 2 diabetes and impaired(More)
BACKGROUND In order to optimize glycaemic control, substantial numbers of people with type 2 diabetes may require transfer from oral medication to insulin therapy. Although insulin conversion is traditionally a specialist secondary care function, as nursing roles change and expand there is growing pressure for this to be performed within primary care.(More)
Unilateral retrobulbar optic neuritis developed in a 43-year-old man with acquired immune deficiency syndrome (AIDS). This was secondary to varicella zoster virus (VZV) as confirmed by cerebrospinal fluid (CSF) polymerase chain reaction (PCR) detection of VZV in the cerebrospinal fluid. There was no typical cutaneous infection and no evidence of retinitis.(More)
Sporadic Creutzfeldt-Jakob disease (CJD) was diagnosed in two Oman Arab men, aged 50 and 75 years respectively, both with a history of rapidly developing dementia and myoclonic jerks. Illness developed over a period of 3 months in the first case and over six months in the second. Electroencephalography in both subjects showed periodic triphasic sharp waves(More)