Patricia A. Reuter-Lorenz

Learn More
There are declines with age in speed of processing, working memory, inhibitory function, and long-term memory, as well as decreases in brain structure size and white matter integrity. In the face of these decreases, functional imaging studies have demonstrated, somewhat surprisingly, reliable increases in prefrontal activation. To account for these joint(More)
Age-related decline in working memory figures prominently in theories of cognitive aging. However, the effects of aging on the neural substrate of working memory are largely unknown. Positron emission tomography (PET) was used to investigate verbal and spatial short-term storage (3 sec) in older and younger adults. Previous investigations with younger(More)
There are many occasions in which humans and other animals must inhibit the production of some behavior or inhibit the processing of some internal representation. Success in inhibitory processing under normal circumstances can be revealed by the fact that certain brain pathologies render inhibitory processing ineffective. These pathologies often have been(More)
The most unexpected and intriguing result from functional brain imaging studies of cognitive aging is evidence for age-related overactivation: greater activation in older adults than in younger adults, even when performance is age-equivalent. Here we examine the hypothesis that age-related overactivation is compensatory and discuss the compensation-related(More)
Neuroimaging studies of normal subjects and studies of patients with focal lesions implicate regions of parietal cortex in verbal working memory (VWM), yet the precise role of parietal cortex in VWM remains unclear. Some evidence (; ) suggests that the parietal cortex mediates the storage of verbal information, but these studies and most previous ones(More)
This article reports 3 experiments that tested a hypothesis regarding the nature of rehearsal in spatial working memory, one in which discrete shifts of spatial selective attention mediate the maintenance of location-specific representations. Experiment 1 demonstrated increases in visual processing efficiency for locations held in working memory, which(More)
Reaction times (RTs) to bimodal (visual and auditory) stimuli were examined using 3 different response systems: saccades, directed manual responses, and simple manual responses. The observed levels of intersensory facilitation exceeded race model predictions and therefore support summation (coactivation) models of bimodal processing. However,(More)
The network of regions shown by functional imaging studies to be deactivated by experimental tasks relative to nominally more passive baselines (task < baseline) may reflect processes engaged during the resting state or "default mode." Deactivation may result when attention and resources are diverted from default-mode processes toward task processes. Aging(More)
The latency to initiate a saccade (saccadic reaction time) to an eccentric target is reduced by extinguishing the fixation stimulus prior to the target onset. Various accounts have attributed this latency reduction (referred to as the gap effect) to facilitated sensory processing, oculomotor readiness, or attentional processes. Two experiments were(More)
Older adults were tested on a verbal working memory task that used the item-recognition paradigm. On some trials of this task, response-conflict was created by presenting test-items that were familiar but were not members of a current set of items stored in memory. These items required a negative response, but their familiarity biased subjects toward a(More)