Patricia A Prolla

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BACKGROUND/OBJECTIVES Epigenetic deregulation may be involved in tumor cell biology, including differentiation, tumor progression, and cell death, and histone acetylation is a major regulatory mechanism of gene transcription. Patterns of global histone modifications have been recently suggested as outcome predictors in cancer patients, but few studies have(More)
Gastric adenocarcinoma is rare in children and adolescents, with about 17 cases under age 21 in the world's literature. We report a case of invasive well-differentiated metastatic gastric cancer in a Brazilian 12-year-old boy without documented familial history of cancer. The patient, diagnosed with metastatic disease, died seven months after surgery. DNA(More)
International society for gastrointestinal hereditary tumours—InSiGHT Published online: 19 May 2015 Springer Science+Business Media Dordrecht 2015 The International Society for Gastrointestinal Hereditary Tumours (InSiGHT) is an international multidisciplinary, scientific organization. Its mission is to improve the quality of care of patients and their(More)
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