Patricia A. Keenan

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The hippocampus has long been presumed the primary site of action of estrogens on cognition; and explicit memory is considered the cognitive function most vulnerable to menopausal loss of estrogen. We hypothesize instead that the prefrontal cortex and its neural circuitry are prime mediators of estrogen's role in cognition. We also propose that previously(More)
OBJECTIVE The study was conducted to systematically investigate previous anecdotal reports of memory decline during pregnancy. STUDY DESIGN We used a longitudinal design to investigate memory in women throughout pregnancy and in the postpartum period. Closely matched, nonpregnant women were similarly studied at equivalent intervals. We also assessed(More)
The increasing prevalence of HIV infection among injection drug users mandates the development of innovative treatments. While extensive clinical experience suggests that acupuncture detoxification is both safe and acceptable to those in withdrawal, little research has been conducted to assess its efficacy as a treatment modality. In this first controlled(More)
Memory and attention were evaluated in 19 women with prospectively documented premenstrual syndrome (PMS) and 17 women without PMS. Testing occurred during the late luteal and follicular phases of the menstrual cycle. Estrogen, progesterone, and FSH levels were obtained on testing days for 23 of the women, while mood measures were obtained for all of the(More)
The research investigated the relationship between spatial frequency and visual field in a facial recognition task. Faces of neutral affect (Ekman, 1979) were tachistoscopically presented to the right or left visual field. The faces were presented alone, or masked with square wave gratings of 1, 24, or 48 cycles/degree, for a duration of 10 msec. Accuracy(More)
Fourteen women with PMS and ten without PMS were evaluated with a battery of neuropsychological tests during the follicular and late luteal phases of two consecutive menstrual cycles. Classification was determined with NIMH diagnostic criteria and prospective record keeping. The results indicated that (1) the PMS women had significant difficulty in learning(More)
OBJECTIVE To examine patient and significant other characteristics as predictors of significant other well-being. METHODS A total of 74 persons with multiple sclerosis (MS) and their significant others participated. Executive functioning was measured using neuropsychological tests. Awareness of cognitive deficit was measured as the discrepancy between the(More)
This study investigated the relationship between visuoperceptual ability and visual memory in dementia. Twenty individuals with probable dementia of the Alzheimer type, 24 individuals with probable vascular dementia, and 20 healthy, elderly adults underwent neuropsychological evaluation. Hierarchical multiple regression analyses suggested that perceptual(More)
Depressed mood is a salient feature of Premenstrual Syndrome (PMS). Fourteen women with prospectively documented PMS and ten without PMS completed the short form of the Beck Depression Inventory (BDI) and the Zung Self-Rating Scale for Depression (Zung-D) during the follicular and late luteal phases of two consecutive menstrual cycles. The short form of the(More)
There have been no systematic investigations of the effects of glucocorticoid treatment on memory in a clinical population despite experimental and clinical evidence that such treatment could cause memory disturbance. We conducted both cross-sectional and longitudinal studies. In Study 1, we administered tests of both hippocampal-dependent explicit memory(More)