Patricia A. Carey

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Accurate protein identification in large-scale proteomics experiments relies upon a detailed, accurate protein catalogue, which is derived from predictions of open reading frames based on genome sequence data. Integration of mass spectrometry-based proteomics data with computational proteome predictions from environmental metagenomic sequences has been(More)
BACKGROUND High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflows. The improved spectral quality enables more accurate de novo sequencing for identification of post-translational modifications and amino acid polymorphisms. RESULTS In this(More)
INTRODUCTION The aim of this study was to determine if anisotropic action potential conduction was altered during development of left ventricular hypertrophy (LVH). METHODS AND RESULTS Isolated guinea pig left ventricular preparations from hearts that had developed LVH were used to measure conduction velocity in longitudinal and transverse orientations to(More)
The classical Erd˝ os-Ko-Rado theorem states that if k ≤ ⌊n/2⌋ then the largest family of pairwise intersecting k-subsets of [n] = {0, 1,. .. , n} is of size n−1 k−1. A family of k subsets satisfying this pairwise intersecting property is called an EKR family. We generalize the EKR property and provide asymptotic lower bounds on the size of the largest(More)
Left ventricular hypertrophy is a major risk factor for cardiovascular morbidity and mortality. Angiotensin-converting enzyme inhibitors, calcium antagonists, and beta-blockers prevent, and cause regression of, left ventricular hypertrophy after short-term therapy. The ability of diuretics to do the same is unclear. We have performed a meta-analysis of(More)
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