Patrice L. Baldeck

Learn More
One of the relevant directions that nanotechnology is taking nowadays is connected with nanomedicine and specifically related to the use of light and nanoparticles in early diagnosis and effective therapeutics of cancer. Noble-metal nanoparticles can act under laser irradiation as effective photothermal transducers for triggering localized hyperthermia of(More)
The effectiveness of a therapeutic agent for cancer stands in its ability to reduce and eliminate tumors without harming the healthy tissue nearby. Nanoparticles peripherally conjugated with targeting moieties offer major improvements in therapeutics through site specificity. In this study we demonstrate this approach by targeting the folate receptor of(More)
Because of the spreading of nonlinear microscopies in biology, there is a strong demand for specifically engineered probes in these applications. Herein, we report on the imaging properties in living cells and nude mice brains of recently developed water soluble blue fluorophores that show efficient diffusion through cell membranes and blood-brain barriers.(More)
Cross-phase modulation (XPM) and induced focusing occur when copropagating ultrafast pulses interact in a nonlinear medium. XPM and induced focusing are investigated as new techniques to control the spectral, temporal, and spatial properties of ultrafast pulses with femtosecond time response. In this paper we review our most recent measurements on (1)(More)
Fabrication of submicrometer structures by two-photon-initiated polymerization is performed with an inexpensive and low-power microlaser. This is made possible by the design of photoinitiators with strong two-photon absorption cross sections. We analyze the influence of both material properties and irradiation conditions on the two-photon polymerization(More)
Complex: Applications in Biological Imaging Using Two-Photon Scanning Microscopy Alexandre Picot,† Anthony D’Aléo,† Patrice L. Baldeck,‡ Alexei Grichine,§ Alain Duperray,§ Chantal Andraud,*,† and Olivier Maury*,† UniVersité de Lyon, Laboratoire de Chimie, CNRS-ENS Lyon, 46 allée d’Italie 69364 Lyon, France, Laboratoire de Spectrométrie Physique, UniVersité(More)
We describe the design of original nanocarriers that allows for ultrahigh chromophore loading while maintaining the photo-activity of each individual molecule. They consist in shells of charged biocompatible polymers grafted on gold nanospheres. The self-organization of extended polymer chains results from repulsive charges and steric interactions that are(More)
We report herein the molecular engineering of an efficient two-photon absorbing (TPA) chromophore based on a donor-donor bis-stilbenyl entity to allow conjugation with biologically relevant molecules. The dye has been functionalized using an isothiocyanate moiety to conjugate it with the amine functions of poly(ethylenimine) (PEI), which is a cationic(More)
The tremendous development of materials with fine tuning of their composition, shape, size and chemical functionalities at the nanometer scale has opened a wide range of applications, particularly in medicine. Metallic nanoparticles are extremely interesting for such developments. The fundamental study of surface plasmon resonance (SPR) versus the(More)
In this work we introduce a new class of multifunctional photodynamic agents based on the coupling of photosensitizer molecules with noble metal nanoparticles, which can be efficiently activated under low light intensity. The favourable modification of the photophysical properties of methylene blue (MB) in MB-loaded Pluronic-nanogold hybrids (Au-PF127-MB)(More)