Patrice Jones

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Although chloroquine-resistance (CQR) in Plasmodium falciparum is increasing and resistance to other blood schizonticidal anti-malarials has been reported, the molecular basis remains unclear. In this study fresh field isolates were obtained from The Gambia, an area of emerging CQR and tested for sensitivity to the anti-malarial drugs mefloquine,(More)
The bacterial cell division gene, ftsZ, was used as a specific probe to show the presence of a symbiotic bacterium in two wild type strains of Drosophila melanogaster. Under stringent hybridization conditions we have shown that the bacterium is transferred to the progeny of these strains from infected mothers and can be eradicated by treatment with the(More)
AIM Change of direction speed (CODS) is an important attribute for many sports and is believed to be influenced by a variety of physical factors. However, there is a lack of consensus as to which physical attributes relate to CODS. The aim of this study was to examine the relationship of several physical attributes to CODS. METHODS Thirty-eight subjects(More)
BACKGROUND AND AIMS Circulating microRNAs (miRNAs) are linked to disease and are potential biomarkers. Vitamin D may modulate miRNA profiles, and vitamin D status has been linked to risk of disease, including cardiovascular disease and cancers. We hypothesise that genotypic variance influences these relationships. We examined the correlations between(More)
Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyond the classic biochemistry that links vitamin D to calcium homeostasis; it explores how vitamin D interacts with light in a broader perspective than simple skin photosynthesis. It examines how the vitamin(More)
Eggs of Xenopus laevis were fertilized in vitro by spermatozoa pre-treated with various concentrations of aziridinyl urea (ethyleneurea) for between 30 and 120 minutes. At 2 and 4 mg/ml for 30 minutes there was a high incidence of abnormal embryos, few of which developed into tadpoles; after 6 and 8 mg/ml no tadpoles were produced. However, the highest(More)
We report here the results of a randomized double blind trial comparing coartemether (CGP56697), a combination of artemether and benflumetol, with pyrimethamine/sulfadoxine (P/S). Two hundred eighty-seven children 1-5 years of age with uncomplicated falciparum malaria were enrolled at two centers in The Gambia between July 1996 and December 1996. Following(More)
Niridazole is an effective schistosomicidal compound which, at lower dose levels, affects schistosome gonads. Its antifertility and possible mutagenic effects after various courses of oral treatment were compared in mice, rats and Japanese quail (Coturnix coturnix japonica). In all three species the meiotic stage of spermatogenesis was particularly(More)