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The authors studied 44 acutely decompensated, hospitalized schizophrenic patients who were placed on a double-blind basis for 10 days in three treatment groups: patients given high, moderate, and standard doses of haloperidol. To assess changes in the patients' concentration, abstract thinking, and ability to respond appropriately they administered two(More)
In this study, chronic schizophrenic outpatients who had been maintained on various neuroleptics for an average of about 4 years had their previous medications (approximately equivalent to 695 mg of chlorpromazine per day) changed abruptly to either pimozide or fluphenazine given in single daily oral doses on a double-blind basis for a period of 52 weeks.(More)
The early signs and symptoms of schizophrenic decompensation are subtle and variegated. Today's community patient often presents with vague complaints of brief duration making it imperative that today's diagnostician be able to recognize and appropriately treat early psychopathology. This paper collates a number of observations of developing psychotic(More)
Cardiac effects of tricyclics and tetracyclics, while common, are most frequently benign and well-tolerated. For older patients with underlying disease, however, closer clinical monitoring is needed. The most common effect of MAOIs in healthy adults taking normal dosages is orthostatic hypotension. The most serious reaction to MAOIs is hypertensive crisis,(More)