Pat Cole

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The purpose of the present investigation was to examine the relationship among upper airway resistance, snoring, and arousals, all measured simultaneously, in nonapneic snorers complaining of excessive daytime sleepiness (EDS). To accomplish this task, we selected a group of nine nonapneic snorers who presented because of snoring, EDS, tiredness, or(More)
Nasal respiratory airflow resistances of awake snorers averaged 0.188 +/- 0.165 Pa/cm3/s (N = 306) and were not elevated beyond the normal range (less than 0.25 Pa/cm3/s). Resistances were decreased substantially from a mean of 0.164 +/- 0.128 to 0.065 +/- 0.037 Pa/cm3/s (N = 72) by a nasal vestibular dilator (Nozovent). Effects of the dilator on breathing(More)
The cellular component of an acute ocular inflammation in rabbits was measured with autologous leukocytes exogenously labeled with 111Indium tropolonate. Inflammation was induced by intravitreal bacterial lipopolysaccharide (LPS). After 16 hr blood was removed, leukocytes separated, labeled with 111Indium tropolonate and reinjected. Three cell fractions(More)
Lateral recumbency causes ipsilateral nasal congestion and contralateral decongestion. Nasal resistances were measured before, during and after the application of pressure either regionally or by lateral recumbency. In some experiments an attempt was made to block the response by local anesthetic injection, splinting the nasal vestibules, or topical(More)
This investigation was undertaken to demonstrate the contributions of dynamic vestibular and mucosal components to nasal air-flow resistance in healthy human adults. The studies were made by video recording of alar movement, electromyography of alar muscle activity, and by computer-assisted plethysmographic measurement of nasal air-flow resistance.(More)
PURPOSE To measure simultaneously blood volume, altered vascular permeability, and leukocyte extravasation in ocular inflammation in rabbits at various times and in different anatomic locations after intravitreal endotoxin (lipopolysaccharide [LPS]). METHODS Nuclides of different emission and decay were used for labeling and then injected intravenously.(More)
Dimensions of the external nose and nostrils and nasal airflow resistances were determined in healthy, young Caucasian, Oriental, and Negro adults. Statistically significant variation between racial groups was found in nasal width and the differential between dorsi-ventral and transverse nostril diameters. Corresponding differences were found also in nasal(More)
It is well known that hearing acuity decreases with age. The precise mechanism responsible for this phenomenon, called presbycusis, is unknown. One hypothesis advanced to explain this loss of acuity implicates chronic exposure to snoring noise. Consequently, the purpose of this study was to investigate whether snoring is associated with hearing loss. We(More)
The objective of this study is to compare the properties of two of the most frequently used acoustic rhinometers: the EcoVision (Hood Laboratories, USA) using the transient technique, and the Rhin2100 (RhinoMetrics, Denmark) using the continuous wide-band technique. In the wide-band rhinometer (Rhin2100), the transient analog signals of traditional(More)