Pascale Satabin

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This experiment compares the cardio- and cerebrovascular effects of modafinil and amphetamine administered to rats. Injections of 300 mg/kg and 600 mg/kg modafinil i.p. had no major effect. In contrast, injection of D-amphetamine sulfate (5 mg/kg i.v.) induced a long-lasting rise in heart rate and in mean arterial blood pressure (MABP). Amphetamine(More)
The effects of modafinil, a vigilance-enhancing drug, on brain metabolism were investigated directly in situ by the 2D COSY 1H-NMR spectroscopy in anesthetized rats. Modafinil (600 mg/kg, i.p.) induced significant increases in both aspartate (72% +/- 15%) and glutamate-glutamine pool (28% +/- 8%) simultaneously with increases in inositol (51% +/- 19%) and(More)
BACKGROUND The objective of this study was to analyze the sensory and cognitive functions associated with activated brain regions characterizing mental strategy relative to degree of expertise in aviation-related tasks. METHODS We used echo-planar functional magnetic resonance imaging (fMRI) technique to examine brain activity in expert pilots (n = 6)(More)
The aim of this work was to study the neurochemical effects in the brain of GABA-transaminase inhibition by systemic administration of gabaculine (100 mg/kg, i.a.) in the rat. In order to investigate neurotransmitter and related amino-acid compartmentation and metabolism, we have developed an original tool: the coupling, in vivo, on the same animal, of 2D(More)
The aim of this study was to investigate the impact on several forms of memory and metabolism of a 5-day combat course including heavy and continuous physical activities and sleep deprivation. Mnemonic performance and biochemical parameters of 21 male soldiers were examined before and at the end of the course. Our results showed that short-term memory(More)
The purpose of this study was to examine the effect of oesophageal loads of glucose, medium (MCT)-and long-chain (LCT) triglycerides, plus treadmill exercise on food intake and body weight in rats. On test days, male rats were administered a gastric aqueous solution of glucose, MCT, LCT or water via an oesophageal tube. One hour later, the animals were(More)
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