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BACKGROUND Mutations in the FRY1/SAL1 Arabidopsis locus are highly pleiotropic, affecting drought tolerance, leaf shape and root growth. FRY1 encodes a nucleotide phosphatase that in vitro has inositol polyphosphate 1-phosphatase and 3',(2'),5'-bisphosphate nucleotide phosphatase activities. It is not clear which activity mediates each of the diverse(More)
Repeated administration of thioacetamide (TA), either intraperitoneally or in drinking water, produced liver cirrhosis in normal Sprague-Dawley rats (SDR) with significant histological alterations similar to those observed in human cirrhosis. In the present study, we evaluated the ability of TA to induce liver cirrhosis in mutant Nagase analbuminaemic SDR.(More)
To express Amino-Nogo, the human Nogo-A cDNA for residues 1±1,040 was ligated into pcDNA3.1MycHis (Invitrogen, Burlingame, California) with an in-frame Myc-His tag. We transfected this plasmid into HEK293T cells and Amino-Nogo was puri®ed with a Ni 2+ resin 10. The human Nogo-66 sequence was ligated into pcAP-5 (ref. 10) in frame with the signal sequence, 6(More)
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