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Evoked field potentials and current-source-density analysis were used to study the olfactory, entorhinal, and perirhinal projections to the hippocampus. In urethane-anesthetized rats, various structures were electrically stimulated, and evoked potentials were mapped using glass micropipettes or multichannel silicon probes. Stimulation of the olfactory bulb,(More)
Synaptic plasticity may depend not only on the afferent fibers but also on the recipient structure. The medial perforant path (MPP) from the entorhinalcortex projects to both the dentate gyrus (DG) and CA3, resulting in excitatory postsynaptic potentials (EPSPs) in both areas. In this study, we showed that long-term depression (LTD) following low-frequency(More)
There is controversy concerning whether orthodromic action potentials originate from the apical or basal dendrites of CA1 pyramidal cells in vivo. The participation of the dendrites in the initialization and propagation of population spikes in CA1 of urethan-anesthetized rats in vivo was studied using simultaneously recorded field potentials and current(More)
We hypothesize that endogenous cholinergic modulation of dendritic processing of hippocampal CA1 is layer specific, and it specifically enhances spike output resulting from basal as compared with the apical dendritic excitation. Laminar profiles of evoked field potentials were recorded in the CA1 area of urethane-anesthetized rats using multichannel silicon(More)
This protocol describes an implementation of recording and analysis of evoked potentials in the hippocampal cortex, combined with lesioning using multichannel silicon probes. Multichannel recording offers the advantage of capturing a potential field at one instant in time. The potentials are then subjected to current source density (CSD) analysis, to reveal(More)
Paired-pulse depression (PPD), a short-term neural plasticity, was studied in hippocampal CA1 of urethane-anesthetized rats in vivo, using field potential recordings and current source density analysis. PPD was robust when an ipsilateral CA3 (iCA3) conditioning pulse of moderate stimulus intensity was followed 30-200 ms later by a contralateral CA3 (cCA3)(More)
Spike backpropagation has been proposed to enhance dendritic depolarization and synaptic plasticity. However, relatively little is known about the inhibitory control of spike backpropagation in vivo. In this study, the backpropagation of the antidromic spike into the dendrites of CA1 pyramidal cells was studied by extracellular recording in(More)
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