Pascal Le Corre

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Purpose. To investigate the influence of complexation between bupivacaine and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the systemic absorption and on the pharmacodynamic effect of bupivacaine following epidural administration in a rabbit model. Methods. Bupivacaine and bupivacaine-HP-β-CD complex were administered according to a randomized and cross-over(More)
Objective: To evaluate the clinical benefit of early adjunctive dexamethasone therapy for severe bacterial meningitis in adults. Design: Multicenter, double-blind, randomized trial initiated in emergency or intensive care units in France and Switzerland. Within 3 h after initiation of an aminopenicillin therapy, patients received dexamethasone (10 mg q. i.(More)
The pharmacokinetics of thiopentone administered at infusion rates ranging 4.5–11.5 mg.kg−1. h−1 for 50–130 h was studied in 6 patients with neurologic evidence of severe cerebral damage. Arterial plasma concentrations of thiopentone were measured during and after discontinuation of the infusion. The postinfusion plasma concentrations were fitted to the one(More)
Purpose. To investigate the spinal disposition, the cerebrospinal fluid (CSF) bioavailability, and the ex vivo meningeal permeability of six homologous pipecoloxylidide local anesthetics and to search for correlations with lipophilicity. Methods. The ex vivo meningeal permeability was studied on fresh specimen of meninges (dura mater and arachnoid mater)(More)
This paper illustrates that the software radio approach is of great interest in the context of future multi-standard environments that will become prevalent as we move towards and beyond 3G. Software radio can facilitate this transition thanks to the digital approach that is associated with. The time has come for experimentation and concrete demonstrations(More)
Objective: The plasma and cerebrospinal fluid (CSF) disposition of yohimbine (YO) and 11-hydroxy-yohimbine (11-OH-YO), after oral administration of a single dose of YO (0.65 mg · kg−1) were studied in young and older healthy subjects and in patients with Alzheimer's disease (AD). Results: Plasma disposition of YO displayed large variability; no significant(More)
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