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Various approaches to T-duality with NSNS three-form flux are reconciled. Non-commutative torus fibrations are shown to be the open-string version of T-folds. The non-geometric T-dual of a three-torus with uniform flux is embedded into a generalized complex six-torus, and the non-geometry is probed by D0-branes regarded as generalized complex submanifolds.(More)
Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but(More)
Autism spectrum disorder (ASD) is one of the most prevalent and highly heritable neurodevelopmental disorders in humans. There is significant evidence that the onset and severity of ASD is governed in part by complex genetic mechanisms affecting the normal development of the brain. To date, a number of genes have been associated with ASD. However, the(More)
It has been argued recently that mirror symmetry exchanges two pure spinors characterizing a generic manifold with SU (3)-structure. We show how pure spinors are modified in the presence of topological D-branes, so that they are still exchanged by mirror symmetry. This exchange emerges from the fact that the modified pure spinors come out as moment maps for(More)
—The three-dimensional data-driven Anatomic Gene Expression Atlas of the adult mouse brain consists of numerized in situ hybridization data for thousands of genes, co-registered to the Allen Reference Atlas. We propose quantitative criteria to rank genes as markers of a brain region, based on the localization of the gene expression and on its functional(More)
The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structures in six individual brains, revealing(More)
The Allen Brain Atlas project (ABA) generated a genome-scale collection of gene-expression profiles using in-situ hybridization. These profiles were co-registered to the three-dimensional Allen Reference Atlas (ARA) of the adult mouse brain. A set of more than 4,000 such volumetric data are available for the full brain, at a resolution of 200 microns. These(More)
We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of the distribution of co-expression networks of a given size. We apply them to the Allen Atlas of the adult(More)
More and more pieces of hardware are getting connected to the Internet every day. Technologies such as Bluetooth or Wi-FI make this process even faster. All these equipments make sense provided they can communicate with each other. Among the communication paradigms that seem suited for such an environment are mobile codes or mobile agents and/or remote(More)
The Allen Atlas of the adult mouse brain is used to estimate the region-specificity of 64 cell types whose transcriptional profile in the mouse brain has been measured in microarray experiments. We systematically analyze the preliminary results presented in [arXiv:1111.6217], using the techniques implemented in the Brain Gene Expression Analysis toolbox. In(More)