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  • Sauveur-Michel Maira, Frédéric Stauffer, +14 authors Carlos García-Echeverría
  • Medicine, Biology
  • Molecular cancer therapeutics
  • 2008 (First Publication: 1 July 2008)
  • The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells, providing unique opportunities forContinue Reading
  • Vito Guagnano, Pascal Furet, +14 authors Diana Graus Porta
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2011 (First Publication: 27 October 2011)
  • A novel series of N-aryl-N'-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast growth factor receptor tyrosine kinases 1, 2, and 3 by rationallyContinue Reading
  • Pascal Furet, Vito Guagnano, +10 authors Giorgio Caravatti
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2013 (First Publication: 1 July 2013)
  • Phosphatidylinositol-3-kinase α (PI3Kα) is a therapeutic target of high interest in anticancer drug research. On the basis of a binding model rationalizing the high selectivity and potency of aContinue Reading
  • Flavio Meggio, A Donella Deana, +7 authors Pascal Furet
  • Biology, Medicine
  • European journal of biochemistry
  • 1995 (First Publication: 1 November 1995)
  • A systematic analysis reveals that out of 20 protein kinases examined, specific for either Ser/Thr or Tyr, the majority are extremely sensitive to staurosporine, with IC50 values in the low nanomolarContinue Reading
  • Lipika Goyal, Supriya K. Saha, +29 authors Andrew X. Zhu
  • Biology, Medicine
  • Cancer discovery
  • 2017 (First Publication: 1 March 2017)
  • Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in many cancers, including intrahepatic cholangiocarcinoma (ICC). The FGFR inhibitorContinue Reading
  • Stefania Sarno, Erika de Moliner, +10 authors Lorenzo A. Pinna
  • Biology, Medicine
  • The Biochemical journal
  • 2003 (First Publication: 15 September 2003)
  • IQA [[5-oxo-5,6-dihydro-indolo(1,2-a)quinazolin-7-yl]acetic acid] is a novel ATP/GTP site-directed inhibitor of CK2 ('casein kinase 2'), a pleiotropic and constitutively active protein kinase whoseContinue Reading