Pascal Favrole

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BACKGROUND Carotid stenting is less invasive than endarterectomy, but it is unclear whether it is as safe in patients with symptomatic carotid-artery stenosis. METHODS We conducted a multicenter, randomized, noninferiority trial to compare stenting with endarterectomy in patients with a symptomatic carotid stenosis of at least 60%. The primary end point(More)
BACKGROUND Headache or neck pain is a frequent symptom of spontaneous cervical artery dissection (sCAD). PATIENTS AND METHODS Patients were drawn from an ongoing hospital-based registry of consecutive cases diagnosed with sCAD. Only patients with isolated pain were included in this series. Pain topography, dynamics, severity and quality, imaging findings(More)
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy) is a small-artery disease of the brain caused by NOTCH3 mutations that lead to an abnormal accumulation of NOTCH3 within the vasculature. We aimed to establish whether immunostaining skin biopsy samples with a monoclonal antibody specific for NOTCH3 could(More)
OBJECTIVE To evaluate whether very early neurologic improvement (VENI) after intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA) perfusion in patients with acute ischemic stroke (AIS) predicts favorable outcome at 3 months. DESIGN Retrospective analysis of prospective data. SETTING Stroke registry at the Stroke Unit, Tenon University(More)
BACKGROUND AND PURPOSE Hyperintensities on diffusion-weighted MRI at the site of venous occlusion have previously been reported in cerebral venous thrombosis (CVT). The frequency of these signal changes according to late venous recanalization was not determined yet. METHODS In a series of 28 patients with recent CVT, the frequency of hyperintense signals(More)
BACKGROUND COL4A1 mutations cause familial porencephaly, infantile hemiplegia, cerebral small vessel disease (CSVD), and hemorrhagic stroke. We recently described hereditary angiopathy with nephropathy, aneurysm, and muscle cramps (HANAC) syndrome in 3 families with closely localized COL4A1 mutations. The aim of this study was to describe the(More)
To the editor, We read with great interest the article by Hsu et al. [1], which highlighted SLC20A2 as a major causative gene of familial idiopathic basal ganglia calcification (IBGC, previously known as Fahr’s disease). Indeed, by means of international recruitment, they found that 41 % of IBGC families carried a SLC20A2 mutation. Recently, Yamada et al.(More)
BACKGROUND Intravenous rt-PA is effective in hyperacute ischemic stroke (HAIS) but is administered only in few patients. OBJECTIVES To report the thrombolysis rate in our stroke unit using a stroke code (SC) protocol with a prenotification system and to analyze the SC impact on the thrombolysis rate in a systematic review. METHODS We report, from 2005(More)
OBJECTIVE To investigate the course of diffusion changes in Wilson disease (WD) and to evaluate their clinical and radiologic correlates. METHODS MRI with fluid-attenuated inversion recovery (FLAIR) and diffusion weighted images (DWI) were performed in 13 symptomatic patients with WD who had typical neurologic manifestations of the disease (sWD patients)(More)
OBJECTIVE Few data exist about post-stroke symptoms of post-traumatic stress disorder (sPTSD) and none on DSM-IV formally diagnosed PTSD (fdPTSD). We investigated the frequency and predictors of sPTSD and fdPTSD 1-6 months after a nondisabling ischemic stroke (IS) or transient ischemic attack (TIA). METHODS Consecutive patients were assessed for sPTSD(More)