Pascal Blanc

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Approaches such as Holonic Manufacturing System (HMS) propose a structure organized as a loosely coupled network of communicating agents to answer in a flexible way to necessities of reactivity and profitability. This paper presents such a Holonic Manufacturing Execution System and illustrates this approach on a real industrial application. On one hand, we(More)
Dogma holds that plasma cells, as opposed to B cells, cannot bind antigen because they have switched from expression of membrane-bound immunoglobulins (Ig) that constitute the B-cell receptor (BCR) to production of the secreted form of immunoglobulins. Here we compare the phenotypical and functional attributes of plasma cells generated by the(More)
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