Pascal Blanc

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Holonic manufacturing execution systems (HMES) are structures organized as a loosely coupled network of communicating agents to answer in a flexible way to necessities of reactivity and profitability. In this paper, we propose a PROSA-based HMES and we illustrate our approach on a real industrial application. The working of this HMES relies on a predictive(More)
Dogma holds that plasma cells, as opposed to B cells, cannot bind antigen because they have switched from expression of membrane-bound immunoglobulins (Ig) that constitute the B-cell receptor (BCR) to production of the secreted form of immunoglobulins. Here we compare the phenotypical and functional attributes of plasma cells generated by the(More)
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