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BACKGROUND Extracts of milk thistle (MT), Silybum marianum, have been used as medical remedies since the time of ancient Greece. Methotrexate is a potentially hepatotxic drug. OBJECTIVES To clarify the hepatoprotective effects of MT on methotrexate. MATERIALS AND METHODS From January 2010 to April 2010, 30 male rats were recruited into three 10-rat(More)
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