Parul U Gandhi

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BACKGROUND Atrial fibrillation (AF) is common in patients with the HeartMate II (HMII) left ventricular assist device (LVAD), but the impact of AF on clinical outcomes is uncertain. OBJECTIVES This study sought to determine the effect of AF on outcomes in patients with the HMII LVAD. METHODS Records of 106 patients who underwent HMII implantation at a(More)
Insulin-like growth factor-binding protein 7 (IGFBP7) is a biomarker that has recently been associated with heart failure and cardiac hypertrophy. The aim of this study was to examine IGFBP7 relative to echocardiographic abnormalities reflecting diastolic dysfunction. One hundred twenty-four patients with ambulatory heart failure with reduced ejection(More)
BACKGROUND Among patients in the emergency department, dyspnea is a common complaint and can pose a diagnostic challenge. Biomarkers are used increasingly to improve diagnostic accuracy and aid with prognostication in dyspneic patients. The purpose of this study was to examine the clinical utility of serum procalcitonin (PCT) for the diagnosis of pneumonia(More)
BACKGROUND BCL-2-associated athanogene 3 (BAG3) is a protein implicated in the cardiomyocyte stress response and genesis of cardiomyopathy. Extracellular BAG3 is measurable in patients with heart failure (HF), but the relationship of BAG3 with HF prognosis is unclear. METHODS BAG3 plasma concentrations were measured in 39 acutely decompensated HF(More)
Little is known regarding objective predictors of cachexia affecting patients with heart failure (HF). We studied 108 stable chronic systolic HF patients with serial echocardiography and biomarker measurements over 10 months. Cachexia was defined as weight loss ≥5 % from baseline or final BMI <20 kg/m(2); 18.5 % developed cachexia. While there were no(More)
OBJECTIVE Psychological constructs are associated with cardiovascular health, but the biological mechanisms mediating these relationships are unknown. We examined relationships between psychological constructs and markers of inflammation, endothelial function, and myocardial strain in a cohort of post-acute coronary syndrome (ACS) patients. METHODS(More)
BACKGROUND The management of patients with heart failure has been evolving given the complex nature of the disease and the increasing number of patients. FINDINGS Biomarkers, and in particular the natriuretic peptides, have been studied to assist with diagnosis, chronic management, and prognosis in patients with heart failure. Several new biomarkers are(More)
BACKGROUND Galectin-3 is a prognostic heart failure biomarker associated with aldosterone-induced myocardial fibrosis; mineralocorticoid receptor antagonists (MRAs) may reduce such fibrosis. We sought to examine outcomes of patients with heart failure with reduced ejection fraction (HFrEF) as a function of galectin-3 and MRA therapy. METHODS A total of(More)
A nondestructive method for sampling from ultrasmall environments has been developed utilizing electrophoresis in nanometer inner diameter capillaries and etched electrochemical detection. The desire to study increasingly smaller biological environments such as mammalian cells has led to the need for capillary electrophoresis techniques with subpicoliter(More)
OBJECTIVES To assess prognostic meaning of worsening renal failure (WRF) occurring during management of chronic heart failure (HF) with reduced ejection fraction. BACKGROUND When WRF develops during titration of HF medical therapy, it commonly leads to less aggressive care. METHODS A total of 151 patients enrolled in a prospective, randomized study of(More)