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BACKGROUND IgA nephropathy (IgAN) is the most prevalent primary chronic glomerulopathy worldwide. Thus, it is of vital importance to search for factors aggravating the disease progress, monitor disease activity and predict disease-specific therapy. C4d is a well-known biomarker of the complement cascade with a potential to meet the above needs. OBJECTIVES(More)
INTRODUCTION Studies have revealed the association between vitamin D deficiency and changes in blood glucose and insulin levels as well as sensitivity of the target tissues to insulin. OBJECTIVE In this study, we examined the effect of adding vitamin D (cholecalciferol ; 50,000 units) to therapeutic regimen of T2DM patients compared to placebo on(More)
1Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran 2Department of Pathology, Isfahan University of Medical Sciences, Isfahan, IR Iran 3Nickan Research Institute, Isfahan, IR Iran 4Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IR Iran *Corresponding Author: Mahmoud(More)
BACKGROUND Renal biopsies play an important role in the diagnosis, management and prognosis of patients with lupus nephritis (LN). OBJECTIVES To determine the correlation between the pathological features of LN and the demographic, clinical and laboratory parameters. PATIENTS AND METHODS This retrospective study was conducted from 2008 to 2014 on all(More)
INTRODUCTION Elevated cholesterol and blood pressure are major risk factors for the development diabetic kidney disease. Possible interactions between these two parameters have not been studied in detail. OBJECTIVES This investigation aims to study the values of blood serum cholesterol, blood pressure and possible correlations between them, in a group of(More)
INTRODUCTION Reactive oxygen species have been shown to be mediators of kidney injury and green tea polyphenols are potent-free radical scavengers. OBJECTIVES In this study we sought to examine whether green tea was able to protect renal toxicity induced by contrast media or not. MATERIALS AND METHODS In this experimental study 40 rats were randomly(More)
INTRODUCTION Dyslipidemia and high blood pressure in diabetic patients increase the risk of microvascular and macrovascular complications. OBJECTIVES This study was conducted to investigate the association between serum lipids and level of blood pressure in type 2 diabetic patients (T2D). PATIENTS AND METHODS A prospective analytical study was carried(More)
Tea is the most common beverage throughout the world. Green tea (Camellia sinensis) is full of flavonoids (1). This herbal drug has a lot of polyphenols, catechin epicatechin, epigallocatechin and epigallocatechin-3-gallate. It also contains other composites like saponins, caffeine, tannins, and some vitamins. Several different investigations have indicated(More)
Diabetic nephropathy is one of the most important complications of diabetes mellitus (1). Recently much attention has been directed toward the use of silymarin in diabetic nephropathy (2). Silymarin possesses antioxidant and antiproteinuric effects in humans and in animal models (2,3). Silymarin seems to have two different effects in diabetic patients(More)
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and its prevalence has been increasing in developed countries. Diabetic nephropathy has become the most common single cause of end-stage renal disease worldwide. Oxidative stress and inflammation factors are hypothesized to play a role in the development of late diabetes(More)