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a per diem from Siemens Medical Solutions and served as a consultant with Lantheus Medical Imaging (North Billerica, MA). All other authors reported no actual or potential conflicts of interest in relation to this document.
AIMS This study investigated the incremental role of echocardiographic-contrast particle image velocimetry (Echo-PIV) in patients with heart failure (HF) for measuring changes in left ventricular (LV) vortex strength (VS) during phases of a cardiac cycle. METHODS AND RESULTS Echo-PIV was performed in 42 patients, including 23 HF patients and 19 controls.(More)
Blood flow patterns are closely linked to the morphology and function of the cardiovascular system. These patterns reflect the exceptional adaptability of the cardiovascular system to maintain normal blood circulation under a wide range of workloads. Accurate retrieval and display of flow-related information remains a challenge because of the processes(More)
BACKGROUND Developing countries face the dual burden of high rates of cardiovascular disease and barriers in accessing diagnostic and referral programs. The aim of this study was to test the feasibility of performing focused echocardiographic studies with long-distance Web-based assessments of recorded images for facilitating care of patients with(More)
BACKGROUND Subendocardial strain analysis is currently feasible in two-dimensional and three-dimensional (3D) echocardiography; however, there is a lack of clarity regarding the most useful strain component for subclinical disease detection. The aim of this study was to test the hypothesis that strain analysis along the direction of strongest and weakest(More)
BACKGROUND Point-of-care (POC) echocardiography may be helpful for mass triage, but such a strategy requires adequately trained sonographers at the remote site. The aim of this study was to test the feasibility of using a novel POC echocardiography training program for improving physicians' imaging skills during preanesthetic cardiac evaluations performed(More)
Analysis of deformations in terms of principal directions appears well suited for biological tissues that present an underlying anatomical structure of fiber arrangement. We applied this concept here to study deformation of the beating heart in vivo analyzing 30 subjects that underwent accurate three-dimensional echocardiographic recording of the left(More)
In pulmonary hypertension (PH), right ventricular (RV) dysfunction and failure is the main determinant of a poor prognosis. We aimed to characterize RV structural and functional differences during adaptive RV remodeling and progression to RV failure in a large animal model of chronic PH. Postcapillary PH was created surgically in swine (n = 21). After an 8-(More)
During a cardiac cycle, the filling and emptying of the left ventricle (LV) are associated with characteristic patterns of blood flow motion. Diastolic filling shows an initial rapidly flowing transmitral jet, which decelerates and is subsequently redirected towards the LV outflow track. During this process of flow redirection, the formation of vortices(More)
BACKGROUND After a transient ischemic episode, the subendocardial region is more severely injured than outer subepicardial layers and may regain a proportionately greater degree of mechanical function in the longitudinal direction. We sought to explore left ventricular (LV) transmural mechanics in patients with ST-segment elevation myocardial infarction(More)