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Brunner's gland adenoma is a very unusual cause of upper gastrointestinal bleeding. We report a 16-year-old boy who presented with upper gastrointestinal haemorrhage from diffuse nodular hyperplasia of Brunner's gland without involvement of the first part of the duodenum. The patient was managed conservatively during his hospital stay, and was doing well… (More)
In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia… (More)
In the first study, 20 male and 20 female volunteers were studied under threat-of-shock and no-threat conditions with respect to anxiety levels, skin conductance, EEG auditory evoked response, and alpha-blocking variables. The threat-of-shock increased anxiety levels, skin conductance level, and fluctuations. The P300 component of the AER was greater in… (More)
Acute cerebellar ataxia in patients with lupus is rare and occurs early in the course of disease. We report a case of acute cerebellar ataxia in a young adult female who recovered completely with intravenous high-dose steroid therapy.
Two peptidomimetic macrocycles, regioisomeric in terms of the position of triazole/amide, have been synthesized. Both undergo self-assembly in a parallel manner but in solvents of opposite polarity, ascribed to (β, β) and (β-D, β-L) hydrogen bonding leading to formation of two different unique classes of organic nanostructures.
BACKGROUND AND PURPOSE When evaluating vaccines for efficacy against gram-negative endotoxemia, the challenge has historically required death of a large percentage of test subjects. We attempted to identify surrogate markers of impending death to allow for early euthanasia without interfering with experimental data collection. METHODS… (More)
BACKGROUND The amyloid precursor protein intracellular domain (AICD) is an intrinsically unstructured molecule with functional promiscuity that plays an important role in determining the fate of the neurons during its degeneration. Its association with Alzheimer disease (AD) recently played a key role in propelling scientists to choose AICD as a major… (More)
A higher proportion of slow acetylator phenotypes has previously been found among bladder cancer patients. In the present study carried out among 77 male bladder cancer patients and 80 non-cancer controls, 59.74% of the patients and 35% of the controls were slow acetylator phenotypes (p < 0.01). The odds of developing bladder cancer was also observed to be… (More)
A 1,4-linked triazole/amide based peptidomimetic macrocycle, synthesized from a triazole amide oligomer of cis-furanoid sugar triazole amino acids, possesses a conformation resembling the D-,L-α-amino acid based cyclic peptides despite having uniform backbone chirality. It undergoes a unique mode of self-assembly through an antiparallel backbone to backbone… (More)
Gorham's disease is a rare benign cause of progressive massive idiopathic osteolysis. The clinician's acute awareness and high degree of suspicion are required for diagnosis because of its rarity and variable clinical presentation. Distinctive radiological and histopathological features may help in this regard. Though eventual stabilisation of the affected… (More)