Paromita Raha

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Background:Histone deacetylases (HDACs) are crucial components of the oestrogen receptor (ER) transcriptional complex. Preclinically, HDAC inhibitors can reverse tamoxifen/aromatase inhibitor resistance in hormone receptor-positive breast cancer. This concept was examined in a phase II combination trial with correlative end points.Methods:Patients with(More)
Ataxia-telangiectasia mutated (ATM) is a major regulator of the DNA damage response. ATM promotes the activation of BRCA1, CHK2, and p53 leading to the induction of response genes such as CDKN1A (p21), GADD45A, and RRM2B that promote cell-cycle arrest and DNA repair. The upregulation of these response genes may contribute to resistance of cancer cells to(More)
A total of 248 randomly selected subjects from urban, semiurban and rural areas of Calcutta was studied serologically for the prevalence of antibody to Toxoplasma gondii using latex agglutination technique. Fifty-nine (23.79%) out of these 248 subjects were found to possess anti-toxoplasma antibody. Seropositivity was found to be higher in females (25%) as(More)