Paramdeep S Baweja

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Repolarization alternans has been considered a strong marker of electrical instability. The objective of this study was to investigate the hypothesis that ischemia-induced contrasting effects on the kinetics of membrane voltage and intracellular calcium transient (Ca(i)T) can explain the vulnerability of the ischemic heart to repolarization alternans.(More)
BACKGROUND The correlation between spontaneous calcium oscillations (S-CaOs) and arrhythmogenesis has been investigated in a number of theoretical and experimental in vitro models. There is an obvious lack of studies that directly investigate how the kinetics of S-CaOs correlates with a specific arrhythmia in the in vivo heart. OBJECTIVES The purpose of(More)
Obesity is an epidemic in the United States. It is an independent risk factor for cardiovascular diseases and associated with reduced life expectancy. The adverse effects are related to direct impact of obesity on cardiovascular system and indirectly through its influence on risk factors. Excessive accumulation of adipose tissue in the myocardium leads to(More)
Coronary artery disease is a major cause of morbidity and mortality in patients with diabetes mellitus and remains one of the largest burdens on health care resources. Prevalence of asymptomatic CAD in this population is high and poses a diagnostic challenge due to lack of overt clinical complaints. At this time there is no clear algorithm to screen for(More)
Takotsubo cardiomyopathy (TCM) is a unique type of cardiomyopathy characterised by left ventricular systolic dysfunction in association with stressful conditions. Patients with this condition usually present with chest pain and dyspnoea, and the presentation can mimic acute coronary syndrome. We present a case of a woman aged 58 years who presented with(More)
Water immersion-induced skin wrinkling (WISW) is dependent on intact peripheral sympathetic function. WISW was hypothesized to reflect autonomic function in subjects without peripheral neuropathy. We prospectively studied 70 healthy subjects (aged 31 ± 8 years, 63% females) without cardiovascular risk factors or neurological disease. All subjects underwent(More)
Pulmonary vein thrombosis (PVT) is a rarely encountered disease entity with varied clinical presentations. It is usually associated with lung carcinoma, lung surgeries and as a complication of the radiofrequency catheter ablation procedure for atrial fibrillation. Its clinical manifestations can vary from mild hemoptysis to lung infarction with hemodynamic(More)
OBJECTIVES To evaluate the clinical utility of and demand for the creatine kinase (CK)-MB assay. METHODS We examined the number of CK-MB tests from 2007 through 2013 while we progressively deemphasized their use. We first removed CK-MB from the acute coronary syndrome (ACS) panel and then from the main menu and observed the demand for the test. We also(More)
OBJECTIVES To construct a model to predict long-term bleeding events following percutaneous coronary intervention (PCI). BACKGROUND Treatment with dual antiplatelet therapy following PCI involves balancing the benefits of preventing ischemic events with the risks of bleeding. There are no models to predict long-term bleeding events after PCI. METHODS We(More)