Parakh Sharma

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3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) are cholesterol-lowering drugs that exert other cellular effects and underlie their beneficial health effects, including those associated with myocardial remodeling. We recently demonstrated that statins induces apoptosis and autophagy in human lung mesenchymal cells. Here, we extend our(More)
The synthesis and biological evaluation of a series of bifunctional acridine-HSP90 inhibitor ligands as telomerase inhibitors is herein described. Four hybrid acridine-HSP90 inhibitor conjugates were prepared using a click-chemistry approach, and subsequently shown to display comparable results to the established telomerase inhibitor BRACO-19 in the(More)
Human genome project provided infrastructure of biological information and essential information of gene sequences make it possible to predict proteins for which there is no experimental evidence. Characterization of hypothetical proteins is provided by sequence similarity with proteins of known function. Aim of this study was to describe Hypothetical(More)
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