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Glutamine synthetase (GS) regulation in Escherichia coli by reversible covalent modification cycles is a prototype of signal transduction by enzyme cascades. Such enzyme cascades are known to exhibit ultrasensitive response to primary stimuli and act as signal integration systems. Here, we have quantified GS bicyclic cascade based on steady state analysis(More)
OBJECTIVE To describe aggressive posterior retinopathy of prematurity (APROP) in a subset of premature babies, having gestational age (GA) of ≥28 weeks and birth weight (BW) of ≥1000 g. DESIGN Retrospective observational case series. SETTING AND PATIENTS Case records of 99 babies, who were diagnosed to have APROP between July 2002 and October 2010 were(More)
AIM To compare the photographic screening for retinopathy of prematurity (ROP) using RetCam 120 with binocular indirect ophthalmoscope (BIO), which is the current gold standard. SETTING AND DESIGN Prospective, comparative study. MATERIALS AND METHODS A total of 87 RetCam examinations were performed on 27 premature babies. They were stored in a separate(More)
BACKGROUND AND OBJECTIVE To study the safety and efficacy of "graded" subthreshold transpupillary thermotherapy (TTT), a novel treatment protocol for chronic central serous chorioretinopathy (CSC) and an alternative to photodynamic therapy (PDT). PATIENTS AND METHODS This retrospective pilot study included 10 eyes with chronic CSC that underwent TTT with(More)
OBJECTIVE To describe the characteristics of babies with severe retinopathy of prematurity (ROP) attending a tertiary referral eye hospital in South India. METHODS Data on consecutive preterm infants with severe ROP presenting between July 2002 and October 2007 were retrieved from medical records. Severe ROP was defined as high risk prethreshold disease(More)
PURPOSE To analyze the level of awareness and knowledge about retinopathy of prematurity (ROP) among pediatricians in Coimbatore, which is a tier two city in South India. MATERIALS AND METHODS A questionnaire was framed on the knowledge attitude and practice (KAP) pattern. The questionnaire was given to 83 practicing pediatricians in government and(More)
PURPOSE To evaluate outcomes of arthroscopic tennis elbow release in a population of patients with chronic, recalcitrant symptoms, a large number of workers' compensation claims, and high occupational demands using standardized outcome measures, including a detailed objective assessment of workplace demands. METHODS We treated 36 patients with chronic(More)
OBJECTIVE. To assess primary care pediatricians' (PCPs') perceptions of caring for children and youth with special health care needs (CYSHCN). METHODS. Cross-sectional survey of Illinois pediatricians. RESULTS. Thirty-five percent of surveys were returned and 26% were analyzed. The top 3 perceived barriers were insufficient time (72%), insufficient(More)
OBJECTIVES To examine effects of shrinkage and modulus on the dynamic development of shrinkage stress as a function of methacrylate conversion and filler loading in a model photocurable dimethacrylate-based resin with a silanized barium glass filler. METHODS BisGMA/TEGDMA samples with filler loading levels of 0-70wt% were evaluated. Irradiation times and(More)
PURPOSE To analyse the clinical characteristics and treatment outcome of zone 1 Fulminate type of Retinopathy of Prematurity (ROP) and compare it to Conventional ROP. METHODS Preterm infants from two neonatal intensive care units (NICU) born between July 2002 and November 2003 were screened for ROP. Cases with Conventional ROP were classified according to(More)