Paolo U. Giacomoni

Learn More
BACKGROUND The physiology of body organs can be affected by gender. Skin and skin appendages are influenced by sex hormones. OBJECTIVE This review work has been undertaken to point out the most conspicuous physiological differences observed between men's and women's skin. METHODS The literature has been searched and relevant results have been gathered.(More)
Ionizing- and ultraviolet-radiation cause cell damage or death by directly altering DNA and protein structures and by production of reactive oxygen species (ROS) and reactive carbonyl species (RCS). These processes disrupt cellular energy metabolism at multiple levels. The formation of DNA strand breaks activates signaling pathways that consume NAD, which(More)
PURPOSE We report on our personal technique and the results of US-guided percutaneous treatment of chronic calcific tendinitis. MATERIAL AND METHODS January 1997 to March 1999, seventy patients with known chronic calcific supraspinatus tendinitis were submitted to the US-guided treatment. All patients had undergone plain radiography, US, and physical and(More)
The physical, chemical, and biochemical factors that accelerate skin aging have been proposed to activate a self-maintained microinflammatory process, one of the expected end results of which is an imbalance in the turnover of macromolecules in the dermis. Surface peroxides are recognized as controllable factors of skin aging, and their accumulation is(More)
Data on the morphological changes induced by UVA or UVB irradiation of A431 epidermoid cells in culture are presented. After irradiation with different doses of UVB (120-2400 J m-2) or UVA (10(4)-10(5) J m-2), the membrane and cytoskeleton of these cells were analysed by immunofluorescence and scanning electron microscopy at different times after exposure(More)
In vivo, UV radiation induces a series of morphological and ultrastructural alterations in human epidermis. These and other changes eventually lead to well described pathological modifications including erythema and cancer. Morphological alterations are easier to detect in cultured cells, such as human keratinocytes or other epithelial cells. One can use(More)
Four RNA-polymerizing activities having different subunit composition can be purified from uninfected and from SPO1-infected Bacillus subtilis. Lysozyme and sodium deoxycholate are used for lysing the cells. Polymin P is used for precipitating nucleic acids and DEAE-cellulose chromatography allows separation of enzymatic activity from the residual Polymin(More)