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In this paper, we report on the first edition of the HEp-2 Cells Classification contest, held at the 2012 edition of the International Conference on Pattern Recognition, and focused on indirect immunofluorescence (IIF) image analysis. The IIF methodology is used to detect autoimmune diseases by searching for antibodies in the patient serum but,(More)
Indirect immunofluorescence is currently the recommended method for the detection of antinuclear autoantibodies (ANA). The diagnosis consists of both estimating the fluorescence intensity and reporting the staining pattern for positive wells only. Since resources and adequately trained personnel are not always available for these tasks, an evident medical(More)
Indirect immunofluorescence (IIF) imaging is the recommended laboratory technique to detect autoantibodies in patient serum, but it suffers from several issues limiting its reliability and reproducibility. IIF slides are observed by specialists at the fluorescence microscope, reporting fluo-rescence intensity and staining pattern and looking for mi-totic(More)
BACKGROUND The recommended method for antinuclear antibodies (ANA) detection is indirect immunofluorescence (IIF). To pursue a high image quality without artefacts and reduce interobserver variability, this study aims at evaluating the reliability of automatically acquired digital images of IIF slides for diagnostic purposes. METHODS Ninety-six sera were(More)
—Chronic obstructive pulmonary disease (COPD) is a slowly progressive disease characterized by airway obstruction. Patients suffering from COPD could report exacerbations, which are deteriorations in respiratory health that worsen the course of the disease. The prompt recognition of an exacerbation from daily variations and its early treatment reduces the(More)
Chronic Obstructive Pulmonary Disease (COPD) is a common preventable and treatable disease characterized by persistent airflow limitations. In COPD, exacerbations are worsening of symptoms beyond day-to-day variations that, if not promptly treated, could worsen the course of disease. This work presents a disease management system that remotely monitors the(More)