Paolo Pellegrino

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In this paper a new approach to ontology visualization is introduced, using a more than 3-dimensional space. The ontology information is represented on a 3D view-port enriched by visual cues. A preliminary application based on the presented principles is described, and results show that the approach is feasible and can actually lead to a more effective(More)
This paper presents a domotic house gateway capable of seamlessly interacting with different devices from heterogeneous domotic systems and appliances. Such a gateway also provides the possibility to automate device cooperation through an embedded rule-based engine, which can be dynamically and automatically updated to accommodate necessities and anticipate(More)
Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase(More)
Nitric oxide (NO), generated in skeletal muscle mostly by the neuronal NO synthases (nNOSμ), has profound effects on both mitochondrial bioenergetics and muscle development and function. The importance of NO for muscle repair emerges from the observation that nNOS signalling is defective in many genetically diverse skeletal muscle diseases in which muscle(More)
Muscular dystrophies are a group of genetic and heterogeneous neuromuscular disorders characterized by the primary wasting of skeletal muscle. In Duchenne muscular dystrophy (DMD), the most severe form of these diseases, the mutations in the dystrophin gene lead to muscle weakness and wasting, exhaustion of muscular regenerative capacity, and chronic local(More)
Dear Sirs, Reduction in the hepatic cytochrome P450 system activity has been described after a vaccination in previous studies [1, 2]. While the mechanism behind such reduction was explained as the consequence of the activity of inflammatory cytokines on the mRNA level of hepatic cytochromes [3], it is unclear what effect this interaction may have in the(More)
Nowadays various are the situations in which people need to interact with a Personal Computer without having the possibility to use traditional pointing devices, such as a keyboard or a mouse. In the latest years, various alternatives to the classical input devices like keyboard and mouse and novel interaction paradigms have been proposed. Particularly,(More)
OBJECTIVE To evaluate epidemiological features of post vaccine acute disseminated encephalomyelitis (ADEM) by considering data from different pharmacovigilance surveillance systems. METHODS The Vaccine Adverse Event Reporting System (VAERS) database and the EudraVigilance post-authorisation module (EVPM) were searched to identify post vaccine ADEM cases.(More)
Annual vaccination against influenza (FluV) is indicated for individuals at risk of developing medical complications because of underlying pathological conditions [1]. Most of these patients are likely to be exposed to drug treatments occasionally characterised by a narrow therapeutic index. The possible effects of FluV on the metabolism of these drugs have(More)
We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of designing a Phase II trial to evaluate the drugs' efficacy in(More)