Paolo Pellegrino

Emilio Clementi16
Sonia Radice9
Marco Pozzi8
Stefania Antoniazzi8
Valentina Perrone8
16Emilio Clementi
9Sonia Radice
8Marco Pozzi
8Stefania Antoniazzi
8Valentina Perrone
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In this paper a new approach to ontology visualization is introduced, using a more than 3-dimensional space. The ontology information is represented on a 3D view-port enriched by visual cues. A preliminary application based on the presented principles is described, and results show that the approach is feasible and can actually lead to a more effective(More)
This paper presents a domotic house gateway capable of seamlessly interacting with different devices from heterogeneous domotic systems and appliances. Such a gateway also provides the possibility to automate device cooperation through an embedded rule-based engine, which can be dynamically and automatically updated to accommodate necessities and anticipate(More)
Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase(More)
We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of designing a Phase II trial to evaluate the drugs' efficacy in(More)
Nitric oxide (NO), generated in skeletal muscle mostly by the neuronal NO synthases (nNOSμ), has profound effects on both mitochondrial bioenergetics and muscle development and function. The importance of NO for muscle repair emerges from the observation that nNOS signalling is defective in many genetically diverse skeletal muscle diseases in which muscle(More)
Muscular dystrophies are a group of genetic and heterogeneous neuromuscular disorders characterized by the primary wasting of skeletal muscle. In Duchenne muscular dystrophy (DMD), the most severe form of these diseases, the mutations in the dystrophin gene lead to muscle weakness and wasting, exhaustion of muscular regenerative capacity, and chronic local(More)
Nowadays various are the situations in which people need to interact with a Personal Computer without having the possibility to use traditional pointing devices, such as a keyboard or a mouse. In the latest years, various alternatives to the classical input devices like keyboard and mouse and novel interaction paradigms have been proposed. Particularly,(More)
Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn's disease are the commonest forms. This disease has a significant prevalence and it is of an unknown aethiology. Five-aminosalicylic acid (5-ASA) and its derivatives(More)
  • Emma Assi, Davide Cervia, Laura Bizzozero, Annalisa Capobianco, Sarah Pambianco, Federica Morisi +5 others
  • 2015
The inflammatory microenvironment induces tumours to acquire an aggressive and immunosuppressive behaviour. Since acid sphingomyelinase (A-SMase) downregulation in melanoma was shown to determine a malignant phenotype, we aimed here to elucidate the role of A-SMase in the regulation of tumour immunogenic microenvironment using in vivo melanoma models in(More)