Paolo Marini

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A multiethnic series of patients with early-onset Parkinson's disease (EOP) was studied to assess the frequency and nature of parkin/PARK2 gene mutations and to investigate phenotype-genotype relationships. Forty-six EOP probands with an onset age of < 45 years, and 14 affected relatives were ascertained from Italy, Brazil, Cuba, and Turkey. The genetic(More)
Damage to nonmotor dopamine (DA)-mediated frontostriatal circuits has been proposed as the main pathophysiological basis of cognitive dysfunction in Parkinson's disease (PD). In the present study, 18 early nondemented drug naive PD patients were investigated, by dual-tracer N-ω-fluoropropyl-2β-carbomethoxy-3β-4-[123I]iodophenyl-nortropane ([123I]FP-CIT)(More)
The aim of the present study was to evaluate the reciprocal relationships between motor impairment, dopaminergic dysfunction, and cerebral metabolism (rCMRglc) in de novo Parkinson’s disease (PD) patients. Twenty-six de novo untreated PD patients were scanned with 123I-FP-CIT SPECT and 18F-FDG PET. The dopaminergic impairment was measured with putaminal(More)
Mutations in the gene leucine-rich repeat kinase 2 (LRRK2) have been recently identified in families with Parkinson's disease (PD). However, the prevalence and nature of LRRK2 mutations, the polymorphism content of the gene, and the associated phenotypes remain poorly understood. We performed a comprehensive study of this gene in a large sample of families(More)
A new procedure has been developed at INFN Frascati Laboratory in order to achieve a very high Hydrogen or Deuterium electrolytic loading into a long and thin Palladium wire. This technique consists in the addition of a very small amount of alkaline–earth elements into a very diluted acidic solution. Because of enhancing pH values around the cathode, during(More)
Taking in considerations the several effects of new kinds of bacteria living in heavy water (discovered by us in 1999), from the point of view of Deuterium (D) overloading inside Palladium (Pd), it was developed (since June 2001) a new kind of electrolyte based on mixture of alcohol and water (both heavy) with proper addition of Strontium (Sr) and Mercury(More)
Systematic studies have been performed in order to achieve very high concentration of Hydrogen (or Deuterium) into a Palladium lattice. In a very diluted acid electrolytic cell a thin Pd cathode wire (100 m) and tick anode Pt wires (0.5 mm) has been used as electrodes in a coaxial geometry. Normalised resistance (R/Ro) of Pd-H wire system has been measured(More)
Fast-neutron-induced fission of ^{238}U at an energy just above the fission threshold is studied with a novel technique which involves the coupling of a high-efficiency γ-ray spectrometer (MINIBALL) to an inverse-kinematics neutron source (LICORNE) to extract charge yields of fission fragments via γ-γ coincidence spectroscopy. Experimental data and fission(More)
The aim of this study was to evaluate the accuracy of different single-photon emission computed tomography (SPECT) reconstruction techniques in measuring striatal N-ω-fluoropropyl-2β-carbomethoxy-3β-4-[123I]iodophenyl-nortropane (123I-FP-CIT) binding in de novo Parkinson’s disease (PD) patients, in order to find a correlation with clinical scales of disease(More)
Distributions of the largest fragment charge, Zmax, in multifragmentation reactions around the Fermi energy can be decomposed into a sum of a Gaussian and a Gumbel distribution, whereas at much higher or lower energies one or the other distribution is asymptotically dominant. We demonstrate the same generic behavior for the largest cluster size in critical(More)