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Invited Paper The last few decades witnessed the birth and growth of a new sensibility to transportation efficiency. In particular, the need for efficient and improved people and goods mobility pushed researchers to address the problem of intelligent transportation systems. This paper surveys the most advanced approaches to the (partial) customization of(More)
— To help sharing knowledge in those contexts where documents and services are annotated with semantic information, such as the Semantic Web, defining and implementing the similarity between sets of concepts belonging to a common ontology may prove very useful. In fact, if both the required and the provided pieces of information (be they textual documents,(More)
The way of collecting sensor data will face a revolution when the newly developing technology of distributed sensor networks becomes fully functional and widely available. Smart sensors will acquire full interconnection capabilities with similar devices, so that run-time data aggregation, parallel computing, and distributed hypothesis formation will become(More)
—This paper presents an evolutionary approach able to process a digital image and detect tracks left by preceding vehicles on ice and snow in Antarctica. Biologically inspired by a colony of ants able to interact and cooperate to determine the shortest path to the food, this approach is based on autonomous agents moving along the image pixels and(More)
Acquired resistance to cisplatin (cDDP) is a multifactorial process that represents one of the main problems in ovarian cancer therapy. Distamycin A is a minor groove DNA binder whose toxicity has limited its use and prompted the synthesis of derivatives such as NAX001 and NAX002, which have a carbamoyl moiety and different numbers of pyrrolamidine groups.(More)
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several(More)
The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX018, and we tested their effects on two human colon(More)