Paolo DePetrillo

Learn More
The short allelic variant of the serotonin transporter protein promoter polymorphism (5HTTLPR) appears to influence binge drinking in college students. Both monoamine oxidase type A (MAOA) and the serotonin transporter protein are involved in the processing of serotonin, and allelic variants are both associated with differences in the efficiency of(More)
Exposure of immature thymocytes to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (10 nM) transiently increased detergent extractable protein kinase C (PKC) activity. The increase was apparent at 7.5 min after exposure of cells to TCDD. At later time points, PKC activity returned to control values. Addition of TCDD to cytosol significantly increased(More)
BACKGROUND Declining serum concentrations of 25-hydroxyvitamin D seen in the fall and winter as distance increases from the equator may be a factor in the seasonal increased prevalence of influenza and other viral infections. This study was done to determine if serum 25-hydroxyvitamin D concentrations correlated with the incidence of acute viral respiratory(More)
Lower plasma methadone levels have been reported in pregnant women receiving methadone maintenance for heroin addiction. Methadone pharmacokinetics was examined in a 24-year-old woman 8 months pregnant with twins, who experienced severe withdrawal symptoms beginning 10-12 hours after her daily 30 mg methadone dose. Methadone plasma concentration-time data(More)
A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45. Earlier program entry was associated with decreased opiate and cocaine use and increased(More)
AIMS AND METHODS In the present study, differences in alcohol consumption behaviour associated with the presence of the short variant (S) of the serotonin transporter promoter polymorphism (5-HTTLPR) was investigated in a Caucasian subset (n = 204) of 268 college students. RESULTS Students who were homozygous for the S allele were more likely to engage in(More)
An alternative regression-based method for estimating the Hurst coefficient of a fractal time series is proposed. A formal mathematical description of the methodology is presented. The geometric relationship of the algorithm to the family of self-similar fractal curves is outlined. The computational structure of the algorithm is optimal for generation of(More)
9-Hydroxy ellipticine (9-OHE), a metabolite of the anti-neoplastic agent ellipticine, is known to bind the aryl hydrocarbon (Ah) receptor in rat lung cytosol and to inhibit aryl hydrocarbon hydroxylase activity (AHH) in rat hepatic microsomes. In this study, the effects of 9-OHE on the transformation of the rat hepatic cytosolic Ah receptor to a form that(More)
Calpains (EC are intracellular calcium-activated cysteine proteases that mediate tissue injury following post-ischemic and post-traumatic stress. Both human HIV protease and calpains share a similar secondary structure, where the active site is flanked by hydrophobic regions. The present study demonstrates that ritonavir, a hydrophobic HIV(More)
Human circulating lymphocytes were isolated and incubated with ethanol. Cytosolic, membrane-bound and total detergent extractable protein kinase C (PKC) activities were measured. Exposure to ethanol (100 mm) resulted in an increase in PKC activity, with membrane-associated PKC activity increasing with respect to cytosolic activity at 5 min of exposure.(More)