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Several oncogenes involved in prostate carcinogenesis activate mitogen-activated protein (MAP) kinases, which can relay both proliferative (via extracellular regulated kinases (ERK)) and apoptotic signals (via jun N-terminal protein kinases (JNK)) to the nucleus. Mitogen-activated protein kinase phosphatase 1 (MKP-1) is induced by several oncogenes in the(More)
The rat pheochromocytoma (PC12) cell line is a model for studying the mechanism of growth factor action. Both epidermal growth factor and nerve growth factor stimulate mitogen-activated protein (MAP) kinase in these cells. Recent data suggest that the transient activation of MAP kinase may trigger proliferation, whereas sustained activation triggers(More)
Many mitogens and human oncogenes activate extracellular regulated kinases (ERKs), which in turn convey proliferation signals. ERKs or mitogen-activated protein (MAP) kinases are inactivated in vitro by MAP kinase phosphatases (MKPs). The gene encoding one of these MKPs, MKP-1, is a serum-inducible gene and is transcriptionally activated by mitogenic(More)
— This paper illustrates the activities under development within the FP7 EU MICIE project. The project is devoted to design and implement an on-line alerting system, able to evaluate, in real time, the level of risk of interdependent Critical Infrastructures (CIs). Such a risk is generated by undesired events and by the high level of interconnection of the(More)
The frequent cytogenetic abnormality--isochromosome 17q [i(17)q]--observed in medulloblastomas (MB) may result in altered expression of the oncosuppressor gene p53 that is located on 17p. p53 expression was therefore evaluated in five MBs and in one MB cell line derived from one of these tumors. Expression levels of p53 utilizing serially diluted(More)
—The paper presents an application of satellite communication dedicated to medical assistance of people living in hazardous social-environmental conditions. This objective has been fulfilled by a consortium between telecommunication firms and public research bodies, in cooperation with the Italian Defense Staff, by means of a telemedicine network, involving(More)
Although in situ hybridization has been in use for almost 30 years, its technically demanding nature, the requirements for optimal tissue fixation and preservation, and the turnaround time for the experiments have prevented this technique from becoming widely used in the surgical pathology setting. The use of nonisotopic reporter molecules, the possibility(More)
In this demonstration we present the MICIE platform for on-line risk assessment in scenarios with heterogeneous interdependent Critical Infrastructures (CIs) such as power distribution networks, power plants, refineries, water distribution networks, transportation systems and telecommunication networks. These CIs are highly exposed to a large number of(More)
In the last few years we have witnessed a strong interest in the protection of Critical Infrastructures (CIs) such as power distribution networks, power plants, refineries, water distribution, transportation systems, hospitals and telecommunication networks. Despite their relevance for public safety and security, these infrastructures are highly exposed to(More)
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