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BACKGROUND AND AIMS The role of fundic tension and stretch mechanoreceptors in triggering transient lower esophageal sphincter (LES) relaxation is still unknown. This information would be useful for the development of effective pharmacologic strategies. To elucidate this topic, gastric contractile activity was modified during isovolumetric gastric(More)
Ringed oesophagus is an increasingly recognised finding in young people presenting with dysphagia and may be related to eosinophilic oesophagitis. Recently, hypotheses regarding potential aetiologies have been proposed but these have not been systemically tested in the majority of reported cases. We report two cases very similar in clinical history and(More)
In 12 patients with secondary hyperparathyroidism, 13 parathyroid tumors detected with the use of sonography and confirmed by fine-needle aspiration biopsy were treated by percutaneous injection of absolute ethanol under ultrasonographic guidance. Indications for this procedure were recurrence of parathyroid tumors after previous subtotal surgery, high(More)
BACKGROUND AND AIM Efficacy of proton pump inhibitors (PPIs) on symptoms of gastroesophageal reflux (GER) is supposed to result from normalization of esophageal acid exposure; however, recent data in selected severe patients have challenged this concept. The aim of the study was to investigate 24-hour esophagogastric pH in unselected patients with GER(More)
E+-cells were studied in 16 patients on continuous ambulatory peritoneal dialysis (CAPD) to evaluate the impairment of cell-mediated immunity. E-rosette forming cells (E-RFC) were below the normal range at the beginning of treatment in 10/16 patients, after which their number increased and reached normal levels in the majority of patients in three to six(More)
BACKGROUND Long-term follow-up studies of achalasia after pneumatic dilation, mostly retrospective, have shown variable results. AIM To examine the outcome of achalasia after pneumatic dilation using a prospective follow-up programme. METHODS One or two dilations (first dilation treatment) in 77 patients to achieve stable (>1 year) remission and(More)
  • R Penagini, M Allocca, +4 authors P A Bianchi
  • 2004
BACKGROUND Morphine reduces the rate of transient lower oesophageal sphincter (LOS) relaxations but its site of action is presently unknown. There are no data available concerning its motor effects on the proximal stomach, an important site for triggering transient LOS relaxations. AIM To evaluate the effect of morphine on the rate of transient LOS(More)
Anti-HCV was tested in 77 uremic patients, 48 on hemodialysis (HD), 29 on CAPD, by immunoenzymatic 1st and 2nd generation assays (ELISA I, II) and 4-antigen (4-RIBA) immublotting. The investigation was extended to the staff (n = 29) and to HCV-positive patients' families (n = 30). The prevalence using 2nd generation tests was double (21%) that in 1st(More)
BACKGROUND AND STUDY AIMS Although surgery remains the gold standard for the treatment of symptomatic common bile duct stenosis associated with chronic pancreatitis, plastic and self-expandable open-mesh stents have been proposed as alternative treatments. These may dysfunction, however, mainly due to stent occlusion by clogging or by hyperplasia of(More)
Gastro-oesophageal reflux disease is a multifactorial disorder in which the pathophysiological mechanisms are variably combined in different patients. Motor dysfunction of the lower oesophageal sphincter (LOS) and, possibly, the proximal stomach is a major cause of the increase in the number of reflux episodes. Transient LOS relaxation is the main mechanism(More)