Paolo Bozzelli

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Much of the research in Alzheimer's disease (AD) that uses mouse models focuses on the early-onset form of the disease, which accounts for less than 5% of cases. In contrast, this study used a late-onset AD model to examine the interaction between increased dietary zinc (Zn) and the apolipoprotein E (ApoE) gene. ApoE ε4 is overrepresented in late-onset AD(More)
Disruptions to daily living, inflammation, and astrogliosis are characteristics of Alzheimer's disease. Thus, circadian rhythms, nest construction, IL-1β and TNF-α, and glial fibrillary acidic protein (GFAP) were examined in a mouse model developed to model late-onset Alzheimer's disease-the most common form of the disease. Mice carrying both the mutated(More)
iii DEDICATION This dissertation is dedicated to my family for the unconditional love and support throughout the entire process of my graduate career. To my husband Matthew Travis for supporting me and standing by my side through all the initials: B. Coates who give me the strength to pursue my life passions and are always there to provide words of love and(More)
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