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In the range of pH examined (5.2-10), variations of internal pH from high to low values result in a reversible decrease of the conductance of the open K channels, without significantly affecting the kinetics parameters. A linear plot of the conductance versus internal pH suggests the existence of a titratable group that has an apparent pKa of about 6.9, and(More)
Squid giant axons were used to investigate the reversible effects of intracellular pH(pHi) on the kinetic properties of ionic channels. The pharmacologically separated K+ and Na+ currents were measured under: (a) internal perfusion, (b) enzymatic Pronase treatment, and (c) continuous estimate of periaxonal ion accumulation. Variation of internal pH from 4.8(More)
Sodium channels in plasma membranes can be blocked by a large variety of toxins and local anaesthetics. This property, however, is not confined to relatively large molecules. For instance, extracellularly applied small ions like hydrogen may also prevent the passive transport of permeant cations across open Na+ channels. A typical feature of this phenomenon(More)
We have analyzed high-resolution X-ray spectra of a sample of 22 active stars observed with the High Energy Transmission Grating Spectrometer on Chandra in order to investigate their coronal plasma density. Densities where investigated using the lines of the He-like ions O VII, Mg XI, and Si XIII. Si XIII lines in all stars of the sample are compatible with(More)
The interior structure of the Sun can be studied with great accuracy using observations of its oscillations, similar to seismology of the Earth. Precise agreement between helioseismological measurements and predictions of theoretical solar models has been a triumph of modern astrophysics. A recent downward revision by 25-35 per cent of the solar abundances(More)
The physical processes causing energy exchange between the Sun's hot corona and its cool lower atmosphere remain poorly understood. The chromosphere and transition region (TR) form an interface region between the surface and the corona that is highly sensitive to the coronal heating mechanism. High-resolution observations with the Interface Region Imaging(More)
An analysis of Lyman series lines arising from hydrogen-like oxygen and neon ions in the coronae of the active RS CVn-type binaries II Peg and IM Peg, observed using the Chandra High Resolution Transmission Grating Spectrograph, shows significant decrements in the Lyα/Lyβ ratios as compared with theoretical predictions and with the same ratios observed in(More)
Aims. We have performed a set of highand low-spectral resolution phase-resolved X-ray observations of the magnetic B star β Cep, for which theoretical models predict the presence of a confined wind emitting X-rays from stationary shocks. Some of the models predict, given the peculiar geometry of β Cep, strong rotational modulation of the X-ray emission,(More)
Squid giant axons were used to study the reversible effects of high intracellular pH (pHi) on gating currents. Under depolarization, when Na channels are activated, internal solutions buffered at high pHi (10.2) affect considerably the time course of gating charge associated with channel closing, QOFF, with almost no alteration of QON records. In(More)
In adults with congenital heart disease who are confronted with noncardiac surgery, perioperative risks can be reduced, often appreciably, when problems inherent to this patient population are anticipated. The first necessity is to clarify the diagnosis and to be certain that appropriate information is obtained from a cardiologist with adequate knowledge of(More)