Soft tissues exhibit a nonlinear, essentially incompressible (visco-) elastic response; a key issue is the active nature of muscle fibres, in other words their ability to contract and relax in response to biochemical signals. Here we present a continuum model able to describe an active elastic medium.
The aim of this study is to investigate human left ventricular heart morphological changes in time among 17 healthy subjects. Preliminarily, 2 patients with volumetric overload due to aortic insufficiency were added to our analyses. We propose a special strategy to compare the shape, orientation and size of cardiac cycle's morphological trajectories in… (More)
The assessment of left ventricular shape changes during cardiac revolution may be a new step in clinical cardiology to ease early diagnosis and treatment. To quantify these changes, only point registration was adopted and neither Generalized Procrustes Analysis nor Principal Component Analysis were applied as we did previously to study a group of healthy… (More)
The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by… (More)
We present a reduced–order heart model with the aim of introducing a novel point of view in the interpretation of the pressure–volume loops. The novelty of the approach is based on the definition of active contraction as opposed to that of active stress. The consequences of the assumption are discussed with reference to a specific pressure-volume loop… (More)