Paola Adele Lonati

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OBJECTIVE Levels of interleukin-17A (IL-17A) have been found to be increased in synovial fluid from individuals with systemic sclerosis (SSc). This study was undertaken to investigate whether IL-17A-producing cells are present in affected SSc skin, and whether IL-17A exerts a role in the transdifferentiation of myofibroblasts. METHODS Skin biopsy samples(More)
OBJECTIVES Interleukin (IL) 22 mRNA in systemic sclerosis (SSc) skin and Th22 cells in SSc peripheral blood are increased, but the role of IL-22 in fibrosis development remains poorly understood. METHODS Biopsies were obtained from the involved skin of 15 SSc, 4 morphea and 8 healthy donors (HD). The presence of IL-22+ cells in the skin was determined by(More)
The insulin receptor substrate protein of 53 kDa (IRSp53) is crucially involved in the formation of filopodia and neurites through mechanisms that have only partially been clarified. We have investigated the role of the small scaffold protein LIN7, which interacts with IRSp53. We found that formation of actin-filled protrusions in neuronal NSC34 cells and(More)
BACKGROUND High interleukin (IL)-17A levels are characteristically found in the skin of systemic sclerosis (SSc) individuals. Our aim was to investigate whether the dermal expression of IL-17A and related IL-17 family members (i.e. IL-17C, IL-17E and IL-17F) could distinguish fibrotic from healthy skin and could show similarities in SSc and morphea, two(More)
LIN7 regulates the filopodia and neurite promoting activity of IRSp53 1 2 3 *Arianna Crespi, *Ilaria Ferrari, Paola Lonati, Andrea Disanza, 1,4 Diego Fornasari, Giorgio 4 Scita, Valeria Padovano, and 1,4,5 Grazia Pietrini. 5 6 1 Department of Medical Biotechnology and Translational Medicine, Università degli Studi di 7 Milano, Milan, Italy 8 2 IFOM, FIRC(More)
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