Pantelis Sopasakis

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In this paper, the strictly convex quadratic program (QP) arising in model predictive control for constrained linear systems is reformulated as a system of piecewise affine equations. A regularized piecewise smooth Newton method with exact line-search on a convex, differentiable, piecewise-quadratic merit function is proposed for the solution of the(More)
OpenTox provides an interoperable, standards-based Framework for the support of predictive toxicology data management, algorithms, modelling, validation and reporting. It is relevant to satisfying the chemical safety assessment requirements of the REACH legislation as it supports access to experimental data, (Quantitative) Structure-Activity Relationship(More)
— The need for reduced-order approximations of dynamical systems emerges naturally in model-based control of very large-scale systems, such as those arising from the discreti-sation of partial differential equation models. The controller based on the reduced-order model, when in closed-loop with the large-scale system, ought to endow certain properties, in(More)
In this paper the continuous time stochastic constrained optimal control problem is formulated for the class of networked control systems assuming that time delays follow a discrete-time, finite Markov chain. Polytopic overapproximations of the system's trajectories are employed to produce a polyhedral inner approximation of the non-convex constraint set(More)
BACKGROUND The NanoSafety Cluster, a cluster of projects funded by the European Commision, identified the need for a computational infrastructure for toxicological data management of engineered nanomaterials (ENMs). Ontologies, open standards, and interoperable designs were envisioned to empower a harmonized approach to European research in nanotechnology.(More)
The prioritisation of chemical compounds is important for the identification of those chemicals that represent the highest threat to the environment. As part of the CADASTER project (http: / /www.cadaster.eu), we developed an online web tool that allows the calculation of the environmental risk of chemical compounds from a web interface. The environmental(More)
— Linear Impulsive Control Systems have been extensively studied with respect to their equilibrium points which, in most cases, are no other than the origin. However, the trajectory of the system cannot be stabilized to arbitrary desired points which imposes a significant restriction towards their utilization in various applications such as drug(More)