Pantelis Sopasakis

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In this paper, the strictly convex quadratic program (QP) arising in model predictive control for constrained linear systems is reformulated as a system of piecewise affine equations. A regularized piecewise smooth Newton method with exact line-search on a convex, differentiable, piecewise-quadratic merit function is proposed for the solution of the(More)
OpenTox provides an interoperable, standards-based Framework for the support of predictive toxicology data management, algorithms, modelling, validation and reporting. It is relevant to satisfying the chemical safety assessment requirements of the REACH legislation as it supports access to experimental data, (Quantitative) Structure-Activity Relationship(More)
— The need for reduced-order approximations of dynamical systems emerges naturally in model-based control of very large-scale systems, such as those arising from the discreti-sation of partial differential equation models. The controller based on the reduced-order model, when in closed-loop with the large-scale system, ought to endow certain properties, in(More)
In this paper the model predictive control (MPC) technology is used for tackling the optimal drug administration problem. The important advantage of MPC compared to other control technologies is that it explicitly takes into account the constraints of the system. In particular, for drug treatments of living organisms, MPC can guarantee satisfaction of the(More)