Learn More
High-dimensional model representation (HDMR) is a general set of quantitative model assessment and analysis tools for improving the efficiency of deducing high dimensional input-output system behavior. RS-HDMR is a particular form of HDMR based on random sampling (RS) of the input variables. The component functions in an HDMR expansion are optimal choices(More)
The attack on the World Trade Center (WTC) created an acute environmental disaster of enormous magnitude. This study characterizes the environmental exposures resulting from destruction of the WTC and assesses their effects on health. Methods include ambient air sampling; analyses of outdoor and indoor settled dust; high-altitude imaging and modeling of the(More)
BACKGROUND Dietary exposure from food to toxic inorganic arsenic (iAs) in the general U.S. population has not been well studied. OBJECTIVES The goal of this research was to quantify dietary As exposure and analyze the major contributors to total As (tAs) and iAs. Another objective was to compare model predictions with observed data. METHODS(More)
— A computationally efficient means for propagation of uncertainty in computational models is provided by the Stochastic Response Surface Method (SRSM), which facilitates uncertainty analysis through the determination of statistically equivalent reduced models. SRSM expresses random outputs in terms of a " polynomial chaos expansion " of Hermite(More)
In this work, a computationally efficient Bayesian framework for the reduction and characterization of parametric uncertainty in computationally demanding environmental 3-D numerical models has been developed. The framework is based on the combined application of the Stochastic Response Surface Method (SRSM, which generates accurate and computationally(More)
NOTICE THE U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described here under Cooperative Agreement CR823717 to the Environmental and Occupational Health Sciences Institute, Rutgers University. It has been subjected to the Agency's peer and administrative review and has(More)
This review summarizes some of the recent developments and identifies critical challenges associated with in vitro and in silico representations of the liver and assesses the translational potential of these models in the quest of rationalizing the process of evaluating drug efficacy and toxicity. It discusses a wide range of research efforts that have(More)
OBJECTIVE The National Children's Study is a long-term epidemiologic study of 100,000 children from 105 locations across the United States. It will require information on a large number of environmental variables to address its core hypotheses. The resources available to collect actual home and personal exposure samples are limited, with most of the home(More)
We have characterized environmental exposures among 187 women who were pregnant, were at or near the World Trade Center (WTC) on or soon after 11 September 2001, and are enrolled in a prospective cohort study of health effects. Exposures were assessed by estimating time spent in five zones around the WTC and by developing an exposure index (EI) based on(More)