Pankaj Vadgama

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Rapid biochemical testing can expedite therapy in key patient categories, particularly intensive care. Dry reagent chemistries have gone some way t o sa t i s fy ing some of t hese requirements. However, chemical and b iosenso r s o f f e r t h e p rospec t s f o r more r o b u s t and operationally simpler near-patient analysers which, furthermore, a re(More)
Polypyrrole (PPy) is a conjugated polymer that displays particular electronic properties including conductivity. In biomedical applications, it is usually electrochemically generated with the incorporation of any anionic species including also negatively charged biological macromolecules such as proteins and polysaccharides to give composite materials. In(More)
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose(More)
Jet lag has potentially serious deleterious effects on performance in athletes following transmeridian travel, where time zones are crossed eastwards or westwards; as such, travel causes specific effects related to desynchronization of the athlete's internal body clock or circadian clock. Athletes are particularly sensitive to the effects of jet lag, as(More)
The surface is of critical importance in determining the in vivo performance and acceptance of an implant, with respect to both tissue and blood. Material surface properties have been studied intensively, but only in recent years have quantitative, mechanistic links been made to biomolecular and cellular interactions driven by the surface. This review(More)
Surface plasmon resonance imaging (SPRI) is a useful tool for the study of surface biomolecular interactions allowing for label-free detection and elegant instrumentation. SPRI imaging system is described in this review with an emphasis on recent applications with examples of different biological interactions and high throughput analysis. Signal(More)
Rapid response needle enzyme electrodes were fabricated to measure the glucose concentration at the centre of a cylindrical spiralled collagen gel, which is a relevant constituent for tissue engineering scaffolds. The experimental data were based on a low consumption glucose sensor which minimised the distorting effect of enzymatic degradation. As the(More)
To enable continuous monitoring of electrochemical sensors outside the laboratories, there is a significant demand on electrochemical measurement systems to be miniaturized. The paper presents a low-cost, portable miniature device for electrochemical measurements. The device consists of a 35mm × 20mm × 25mm wireless tag, which enables(More)
MicroRNAs (miRNAs) show great potential for disease diagnostics due to their specific molecular profiles. Detection of miRNAs remains challenging and often requires sophisticated platforms. Here we report a multienzyme-functionalized magnetic microcarriers-assisted isothermal strand-displacement polymerase reaction (ISDPR) for quantitative detection of(More)