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Routers classify packets to determine which flow they belong to, and to decide what service they should receive. Classification may, in general, be based on an arbitrary number of fields in the packet header. Performing classification quickly on an arbitrary number of fields is known to be difficult, and has poor worst-case performance. In this paper, we(More)
Internet routers that operate as firewalls, or provide a variety of service classes, perform different operations on different flows. A flow is defined to be all the packets sharing common header characteristics; for example a flow may be defined as all the packets between two specific IP addresses. In order to classify a packet, a router consults a table(More)
The process of categorizing packets into “flows” in an Internet router is called packet classification. All packets belonging to the same flow obey a pre-defined rule and are processed in a similar manner by the router. For example, all packets with the same source and destination IP addresses may be defined to form a flow. Packet classification is needed(More)
Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of synaptic glutamate is handled by the glutamate transporter GLT1 (also known as EAAT2; refs 1, 2), the physiologically dominant astroglial protein. In spite of its critical importance in normal and abnormal synaptic activity, no practical pharmaceutical can(More)
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was characterized by activating mutations in genes regulating(More)
Increased bandwidth in the Internet puts great demands on network routers; for example, to route minimum sized Gigabit Ethernet packets, an IP router must process about packets per second per port. Using the “rule-of-thumb” that it takes roughly 1000 packets per second for every 106 bits per second of line rate, an OC-192 line requires routing lookups per(More)
WTF ("Who to Follow") is Twitter's user recommendation service, which is responsible for creating millions of connections daily between users based on shared interests, common connections, and other related factors. This paper provides an architectural overview and shares lessons we learned in building and running the service over the past few years.(More)
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of 37 tumours and matched normal blood. One-hundred and thirty-six genes harbouring somatic mutations in this discovery set were sequenced in an additional 56 medulloblastomas.(More)