Pankaj Daga

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Accurate localization of the optic radiation is key to improving the surgical outcome for patients undergoing anterior temporal lobe resection for the treatment of refractory focal epilepsy. Current commercial interventional magnetic resonance imaging (MRI) scanners are capable of performing anatomical and diffusion weighted imaging and are used for(More)
OBJECTIVE We assessed whether display of optic radiation tractography during anterior temporal lobe resection (ATLR) for refractory temporal lobe epilepsy (TLE) can reduce the severity of postoperative visual field deficits (VFD) and increase the proportion of patients who can drive and whether correction for brain shift using intraoperative MRI (iMRI) is(More)
OBJECTIVE Anterior temporal lobe resection (ATLR) is an effective treatment for refractory temporal lobe epilepsy but may result in a contralateral superior visual field deficit (VFD) that precludes driving in the seizure-free patient. Diffusion tensor imaging (DTI) tractography can delineate the optic radiation preoperatively and stratify risk. It would be(More)
We demonstrate the use of a probabilistic generative model to explore the biomarker changes occurring as Alzheimer's disease develops and progresses. We enhanced the recently introduced event-based model for use with a multi-modal sporadic disease data set. This allows us to determine the sequence in which Alzheimer's disease biomarkers become abnormal(More)
Current state of the art neurosurgical systems do not exploit the complementary information provided by structural and diffusion MRI when aligning pre-operative and intra-operative images. We propose a multivari-ate registration scheme where structural and fractional anisotropy data are combined in a single similarity measure. We formulate the normalised(More)
PURPOSE To report a novel magnetic resonance imaging measure (diffusion orientational complexity [DOC]) in a study of people with multiple sclerosis (MS) and healthy controls and to determine patterns of abnormality, correlations with conventional diffusion measures, and associations with cognitive function. MATERIALS AND METHODS We performed high angular(More)
The Free-Form Deformation (FFD) algorithm is a widely-used approach for non-rigid registration. Modifications have previously been proposed to ensure topology preservation and invertibility within this framework. However, in practice, none of these yield the inverse transformation itself, and one loses the parsimonious B-spline parameterisation. We present(More)