Pandurang Dhabale

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The purpose of the present study was to develop ophthalmic gel formulations of fluconazole. Intraocular delivery of topically applied drugs such as fluconazole is hampered by elimination of the solution due to tear turnover, so an in situ gelling thermoreversible mucoadhesive gel was formulated. Thermoreversible mucoadhesive gels were prepared using the(More)
The aim of the present work was to prepare and evaluate sustained release liquisolid compact formulations of tramadol hydrochloride. The dissolution profile of the prepared compacts was also compared to that of a marketed preparation. Liquisolid sustained release formulations were prepared by using HPMC K4M as a sustained release agent. Precompression(More)
ISSN:0975-542X Ginseng is the most popular herb. Ginseng is often referred as the ultimate tonic; the herb boosts general well-being, immune function, libido, and athletic performance. Ginseng is popularly used for its adaptogenic, antineoplastic, immunomodulatory, cardiovascular, CNS, endocrine, and ergogenic effects, but these uses have not been confirmed(More)
Atorvastatin– fenofibrate combination used in the treatment of hypercholesterolemia and hypertriglyceridemia. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of atorvastatin – fenofibrate from tablet formulation. The drug(More)
Paracetamol is an analgesic and antipyretic drug and Nimesulide is an non steroidal anti-inflammatory drug. simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Paracetamol and Nimesulide in tablet dosage form have been developed. Method employs formation and solving of simultaneous(More)
A sensitive and reliable high performance thin layer chromatographic method has been developed for quantitation of quercetin in the dried flowers of Nymphaea stellata willd. The hydroalcoholic extract of N. stellata was chromatographed on silica gel 60 F254 plates with toluene: ethyl acetate: formic acid, 5: 4: 0.2 (v/v/v), as mobile phase. Detection and(More)
Ranitidine Hydrochloride is H2 – receptor antagonist indicated for duodenal ulcer. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed two new, precise and simple UV spectrophotometric methods for estimation of Ranitidine Hydrochloride from tablet formulation. The drug obeyed the Beer’s law and(More)
A simple, accurate, precise and economical procedure for simultaneous estimation of tramadol hydrochloride and paracetamol in two component tablet dosage form has been developed utilizing concept of internal standard addition. The method is based upon determination of tramadol hydrochloride at 270.5 nm and paracetamol at 243.5 nm, in distilled water.(More)
Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formulation into liquisolid tablets and then to investigate in vitro performance of prepared liquisolid systems. By use of this technique,(More)
The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile comparison include Model independent method (Similarity(More)