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Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice.
CONTEXT Germline mutations in genes coding succinate dehydrogenase (SDH) subunits A, B, C, and D have been identified in familial paragangliomas (PGLs)/pheochromocytomas (PHEOs) and other tumors. WeExpand
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Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy
Significance Therapeutically relevant lung gene therapy is yet to be achieved. We introduce a highly translatable gene delivery platform for inhaled gene therapy based on state-of-the-artExpand
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Convection enhanced delivery of cisplatin‐loaded brain penetrating nanoparticles cures malignant glioma in rats
ABSTRACT Glioblastoma multiforme (GBM) is highly invasive and uniformly fatal, with median survival < 20 months after diagnosis even with the most aggressive treatment that includes surgery,Expand
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Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.
Effective blood-brain tumor barrier penetration and uniform solid tumor distribution can significantly enhance therapeutic delivery to brain tumors. Hydroxyl-functionalized, generation-4Expand
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Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain.
Gene delivery to the central nervous system (CNS) has potential as a means for treating numerous debilitating neurological diseases. Nonviral gene vector platforms are tailorable and can overcome keyExpand
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The anatomy and immunology of vasculature in the central nervous system
This review discusses the immunology of central nervous system vasculature from a neuroanatomical perspective. Barriers between circulation and the central nervous system (CNS) play a key role in theExpand
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Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound.
Gene therapy holds promise for the treatment of many pathologies of the central nervous system (CNS), including brain tumors and neurodegenerative diseases. However, the delivery of systemicallyExpand
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Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells.
Ocular gene therapy holds promise for the treatment of numerous blinding disorders. Despite the significant progress in the field of viral and non-viral gene delivery to the eye, significantExpand
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Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microglial and human retinal pigment epithelial cells.
Triamcinolone acetonide (TA) is a potent, intermediate-acting, steroid that has anti-inflammatory and anti-angiogenic activity. Intravitreal administration of TA has been used for diabetic macularExpand
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Cyst formation after stereotactic radiosurgery for brain arteriovenous malformations: a systematic review.
OBJECTIVE Cyst formation can occasionally occur after stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVMs). Given the limited data regarding post-SRS cyst formation inExpand
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