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LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner
TLDR
This study revealed that H19 and HULC, up-regulated by oxidative stress, regulate CCA cell migration and invasion by targeting IL-6 and CXCR4 via ceRNA patterns of sponging let-7a/let-7b and miR-372/miR-373, respectively. Expand
MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways
TLDR
MiR-100 and miR-99a have critical roles in altering cellular processes by targeting both the FKBP51 and IGF1R/mTOR signalling pathways in vitro and might represent a potential novel strategy for ALL treatment. Expand
Genome-wide screen identified let-7c/miR-99a/miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma
TLDR
Findings showed potential links between miRNAs and inflammation, and provide a potential treatment strategy for developing an miRNA-based therapy via IL-6/STAT3 targeting for CCA. Expand
MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia
TLDR
MIR125B1 dysregulation may interfere with the effectiveness of ATRA-mediated differentiation through an autophagy-dependent pathway, representing a novel potential APL therapeutic target. Expand
Global identification and characterization of lncRNAs that control inflammation in malignant cholangiocytes
TLDR
These findings are the first to show that lncRNAs may not only be potential biomarkers of CCA progression but also respond to inflammation in CCA. Expand
Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution.
TLDR
The heterogeneity and interacting molecules of the TME in NPC are uncovers at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC. Expand
Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
TLDR
The adult human cell atlas reveals the inter- and intra-organ heterogeneity of cell characteristics and provides a useful resource in uncovering key events during the development of human diseases in the context of the heterogeneity of cells and organs. Expand
Microbial cell-free DNA in plasma of patients with sepsis: a potential diagnostic methodology.
TLDR
The presence of pathogen-derived circulating DNA in the plasma of patients with sepsis was showed, and the sizes of circulating DNA fragments derived from pathogenic bacteria showed a skewed unimodal distribution, while those derived from host cells showed a normal unimmodal distribution. Expand
Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
TLDR
The adult human cell atlas reveals the inter- and intra-organ heterogeneity of cell characteristics and provides a useful resource in uncovering key events during the development of human diseases in the context of the heterogeneity of cells and organs. Expand
X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma
TLDR
This finding reveals new susceptibility loci at the X chromosome conferring risk of NPC and supports the value of including the X chromosomes in large-scale association studies. Expand
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