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he basal ganglia are large subcortical nu-clei, including the dorsal striatum, that are strongly interconnected with the neocortex. An increasing number of evidence indicates that the basal ganglia play a central Introduction: The dorsal striatum plays an important role in the control of motor activity and learning processes within the basal ganglia(More)
Parkinson's disease (PD) is a neurological disorder characterized by the manifestation of motor symptoms, such as akinesia, muscle rigidity and tremor at rest. These symptoms are classically attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra (SNc), which results in a marked dopamine depletion in the striatum. It is(More)
In addition to GABA and glutamate innervations, the globus pallidus (GP) receives dopamine afferents from the pars compacta of the substantia nigra (SNc), and in turn, sends inhibitory GABAergic efferents to the subthalamic nucleus (STN) and the pars reticulata of the substantia nigra (SNr). Nevertheless, the role of dopamine in the modulation of these(More)
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