Pamita Awasthi

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Solution conformation of self-complementary DNA duplex d-CGATCG, containing 5' d-CpG 3' site for intercalation of anticancer drug, daunomycin and adriamycin, has been investigated by nuclear magnetic resonance (NMR) spectroscopy. Complete resonance assignments of all the protons (except some H5'/H5" protons) have been obtained following standard procedures(More)
The anthracycline antibiotic daunomycin, having four fused rings and an amino sugar, is being used in the treatment of acute leukemia. Binding to DNA is generally believed to be essential for its activity. We have studied the interaction of daunomycin with DNA hexamer sequence d-(TGATCA)2 by titrating up to two drug molecules per duplex using nuclear(More)
The interaction of mitoxantrone with alternating Poly(dG-dC).Poly(dG-dC) and Poly(dA-dT).Poly(dA-dT) duplex has been studied by absorption, fluorescence and Circular Dichroism (CD) spectroscopy at Drug to Phosphate base pair ratios D/P=20.0-0.04. Binding to GC polymer occurs in two distinct modes: partial stacking characterized by red shifts of 18-23nm at(More)
Titanium complexes have been synthesized by the reaction between titanium tetrachloride (TiCl4), respective bidentate ligand [4,4' -dimethoxy-2,2' -bipyridine (bpome), 6,6'-dimethyl-2,2'-bipyridine (dpme), 1,2-diaminocyclohexane (dach), 1,10-phenanthroline (phen), and benzoylacetone (bzac)], and adamantylamine (ada) in 1 : 2 : 2 molar ratios, respectively.(More)
Mixed-ligand titanium complexes have been synthesized by reacting titanium tetrachloride (TiCl4), benzoylacetone (bzac), and respective bidentate ligands [2,2′-bipyridine (bipy), 4,4′-dimethyl-2,2′-bipyridine (bpme), 4,4′-dimethoxy-2,2′-bipyridine (bpome), 6,6′-dimethyl-2,2′-bipyridine (dpme)], in 1:1:1 molar ratios, respectively. The structure of(More)
Virtual screening emerged as an important tool in our quest to access novel pesticides like compounds. The capability to propose feasible ways of binding a putative ligand to a known receptor site is crucial to the structure – based drug design. Molecular docking is one of the most important methods in computer assisted screening of compounds. A docking(More)
Titanium complexes with and without labile groups have been synthesized by the reaction of titanium tetrachloride (TiCl4) with N- containing ligands (1,2-diaminocyclohexane (dach), 1,10-Phenanthroline (phen) and adamantylamine (ada), 2,2'-bipyridine (bipy), 4,4'-dimethyl-2,2'-bipyridine (bpme)) in 1:2 and 1:2:2 molar ratio respectively. The synthesized(More)
  • Priyanka Sharma, Sunil Thakur, Pamita Awasthi
  • Journal of biomolecular structure & dynamics
  • 2016
Juvenile hormone (JH) analogs are nowadays in use to control harmful pests. In order to develop new bioactive molecules as potential pesticides, we have incorporated different active structural features like sulfonamide, aromatic rings, amide group, and amino acid moiety to the base structure. We have screened a series of designed novel JH analogs against(More)
Numbers of drugs are being synthesized every year to meet the target of safe and disease-free society. Presently molecular modeling technique is used to unfold the mechanism of action of drugs alone or in conjunction with experimental methodologies. There are a number of drugs which are successfully developed using this methodology. Mitoxantrone (MTX) - 1,(More)