Pamela W. Roy

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We have shown that dicyanogold(I), [Au(CN)(2)](-) is a common metabolite found in blood and urine samples of patients treated with different gold based drugs. Some patients have high levels of gold within their red blood cells (RBCs). Size exclusion and C18 reversed phase chromatography show that the majority of the gold in RBC lysates is bound to protein,(More)
Visceral leishmaniasis is an endemic protozoal disease of humans and dogs in tropical and subtropical regions in Asia, Africa, southern Europe, Central America, and South America, where sand flies (genera Phlebotomus and Lutzomyia) act as vectors. An outbreak in a New York foxhound kennel and subsequent surveillance revealed widespread Leishmania infantum(More)
A simple method is described for primary culture and for maintenance of hormone-producing cells from normal human placenta. A consistent yield of cells was obtained and an average survival of 3 to 4 months in culture using 1 mm3 explants from the most vascular area of the placentas. These explants were placed in a variety of culture media in 30 ml flasks(More)
Having identified dicyanogold(I) as a common metabolite of gold-based antiarthritis drugs, we are investigating the effects of the compound on the production of lymphokines. Handel, et al. 1 suggested that the transcription factor AP-1, critical to the production of a number of cytokines, might be the target for gold compounds because of a critical cysteine(More)
Our analyses of blood and urine samples from patients treated with gold-based antiarthritis drugs have shown that the dicyanogold(I) anion, [Au(CN)2]’, is a common metabolite. Previous work by Graham had suggested that [Au(CN)2]" would form as a result of interaction of any of the goldbased drugs with cyanide and that [Au(CN)2]" would be readily taken up by(More)
At present the only vaccines used against bluetongue (BT) disease are live-attenuated virus vaccines. Since viruses with RNA genomes such as BT virus (BTV) have a high frequency of mutations, live virus vaccines could have breakthroughs (vaccine failures) and mutate into virulent strains. In addition, multiple BTV serotypes exist in nature which could(More)
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